EFFECT OF INDOLE AND 5-HYDROXYINDOLE 2- CARBOXYLIC ACID IN ALLOXAN-INDUCED DIABETIC AND NON-DIABETIC RATS

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YAGHMAEI PARICHEHR; EBRAHIM HABIBI AZADEH; ADINEH FARZANEH; NASROLLAHI MASOMEH; HAYATI ROODBARI NASIM

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2013 | Volume:3 | Issue:11 Page(s): 69-76

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Title

EFFECT OF INDOLE AND 5-HYDROXYINDOLE 2- CARBOXYLIC ACID IN ALLOXAN-INDUCED DIABETIC AND NON-DIABETIC RATS

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Keywords

DIABETESQ2

INDOLEQ2

5-HYDROXYINDOLE 2- CARBOXYLIC ACIDQ2

ALLOXANQ2

Abstract

Aim and Background: The most widespread disease related to abnormal carbohydrate metabolism is DIABETES mellitus. This disease is due to insulin secretion deficiency or failure in performance or both. It is known that melatonin may be involved in carbohydrate metabolism. In this study, the effect of compounds including INDOLE ring (as melatonin precursor) has been observed on non-diabetic and diabetic rats.Materials and methods: Diabetic and non-diabetic rats were divided into 4 groups as follows: control group: diabetic and non-diabetic rats that received water and normal food daily; sham group: diabetic and non-diabetic rats that received water and normal food in 0.5 ml grape seed oil daily; Exp1&2 groups: diabetic and non-diabetic rats that received daily 4 mg/kg INDOLE or 4mg/kg5-hydroxy INDOLE 2- carboxylic acid in 0.5ml oil respectively. Diabetizing with ALLOXAN was performed using 150 mg/kg dose with a single IP injection. In this study, blood sugar, average urine and water consumption, and blood insulin levels were measured, and pancreas as well as histological studies were performed.Results: After treatment for 30 days, the exp1D showed significantly decreased blood sugar levels, water consumption and urine (p<0.001) while insulin levels also increased in this group (p<0.001). The compound used in exp 2D had less effect on insulin levels, blood sugar and the water consumption and urine. Histological studies also showed that INDOLE has caused reparative effects in the exp1D pancreatic tissue.Conclusion: INDOLE may have beneficial effects in decreasing blood sugar and increasing insulin synthesis and reparative effect on pancreas.

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APA: Copy

YAGHMAEI, PARICHEHR, EBRAHIM HABIBI, AZADEH, ADINEH, FARZANEH, NASROLLAHI, MASOMEH, & HAYATI ROODBARI, NASIM. (2013). EFFECT OF INDOLE AND 5-HYDROXYINDOLE 2- CARBOXYLIC ACID IN ALLOXAN-INDUCED DIABETIC AND NON-DIABETIC RATS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 3(11), 69-76. SID. https://sid.ir/paper/204641/en

Vancouver: Copy

YAGHMAEI PARICHEHR, EBRAHIM HABIBI AZADEH, ADINEH FARZANEH, NASROLLAHI MASOMEH, HAYATI ROODBARI NASIM. EFFECT OF INDOLE AND 5-HYDROXYINDOLE 2- CARBOXYLIC ACID IN ALLOXAN-INDUCED DIABETIC AND NON-DIABETIC RATS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2013;3(11):69-76. Available from: https://sid.ir/paper/204641/en

IEEE: Copy

PARICHEHR YAGHMAEI, AZADEH EBRAHIM HABIBI, FARZANEH ADINEH, MASOMEH NASROLLAHI, and NASIM HAYATI ROODBARI, “EFFECT OF INDOLE AND 5-HYDROXYINDOLE 2- CARBOXYLIC ACID IN ALLOXAN-INDUCED DIABETIC AND NON-DIABETIC RATS,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 3, no. 11, pp. 69–76, 2013, [Online]. Available: https://sid.ir/paper/204641/en

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