EFFECT OF SILIBININ ON THE METABOLIC ACTIVITY OF THE 8305C CELL LINE IN THYROID CANCER

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VAHDATIRAD VASIMEH; GHAFFARI SEYED HAMIDOLLAH; MOMENY MAJID; SHAHBANI ZAHIRI HOSSEIN

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2013 | Volume:3 | Issue:12 Page(s): 25-30

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Title

EFFECT OF SILIBININ ON THE METABOLIC ACTIVITY OF THE 8305C CELL LINE IN THYROID CANCER

Author(s)

VAHDATIRAD VASIMEH | GHAFFARI SEYED HAMIDOLLAH | MOMENY MAJID | SHAHBANI ZAHIRI HOSSEIN | Issue Writer Certificate

Keywords

ANAPLASTIC THYROID CANCERQ2

SILIBININQ2

MTT ASSAYQ1

Abstract

Aim and Background: Anaplastic carcinoma is the most dangerous form of thyroid cancer. It is a rare and aggressive form of thyroid cancer. It grows very rapidly and does not respond to therapy. In this study the effect of SILIBININ on the metabolic activity of a cancerous cell line (8305c) of anaplastic thyroid carcinoma was investigated. SILIBININ is a flavonoid that is the major active constituent of the extract of the Milk thistle seeds. SILIBININ has been demonstrated to have strong pleiotropic anti-cancer effects against various human carcinoma cells.Materials and methods: The 8305c cell cultures were treated with SILIBININ at 25, 50, 75, and 100 μmol in the MTT plates. After 24 and 48 hours, the metabolic activity of the treated cells was studied using the MTT ASSAY. The MTT ASSAY is a colorimetric method for determination of cell viability and cytotoxicity effects.Results: The results of this study show that SILIBININ has significant cytotoxicity effects on the 8305c cell line. The treatment of the cells with SILIBININ at the given concentrations resulted in significant decrease of metabolic activity in a time and dose dependent manner.Conclusion: From the results obtained by this study It may be concluded that SILIBININ significantly reduces the growth of ANAPLASTIC THYROID CANCERous cells. More investigation is underway to reveal the mechanism by which SILIBININ prevents cancer metastasis.

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APA: Copy

VAHDATIRAD, VASIMEH, GHAFFARI, SEYED HAMIDOLLAH, MOMENY, MAJID, & SHAHBANI ZAHIRI, HOSSEIN. (2013). EFFECT OF SILIBININ ON THE METABOLIC ACTIVITY OF THE 8305C CELL LINE IN THYROID CANCER. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 3(12), 25-30. SID. https://sid.ir/paper/204677/en

Vancouver: Copy

VAHDATIRAD VASIMEH, GHAFFARI SEYED HAMIDOLLAH, MOMENY MAJID, SHAHBANI ZAHIRI HOSSEIN. EFFECT OF SILIBININ ON THE METABOLIC ACTIVITY OF THE 8305C CELL LINE IN THYROID CANCER. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2013;3(12):25-30. Available from: https://sid.ir/paper/204677/en

IEEE: Copy

VASIMEH VAHDATIRAD, SEYED HAMIDOLLAH GHAFFARI, MAJID MOMENY, and HOSSEIN SHAHBANI ZAHIRI, “EFFECT OF SILIBININ ON THE METABOLIC ACTIVITY OF THE 8305C CELL LINE IN THYROID CANCER,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 3, no. 12, pp. 25–30, 2013, [Online]. Available: https://sid.ir/paper/204677/en

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