IN VITRO EVALUATION OF ANTICANCER ACTIVITY OF BREVININ-2R AGAINST AGS CELL LINE

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HASANVAND JAMADI ROBAB; ASADI ASADOLLAH; HASANVAND JAMADI MEHDI

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2013 | Volume:3 | Issue:12 Page(s): 107-110

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Title

IN VITRO EVALUATION OF ANTICANCER ACTIVITY OF BREVININ-2R AGAINST AGS CELL LINE

Author(s)

HASANVAND JAMADI ROBAB | ASADI ASADOLLAH | HASANVAND JAMADI MEHDI | Issue Writer Certificate

Keywords

BREVININ-2RQ2

AGSQ2

CYTOTOXICITY OF PEPTIDEQ2

VIABILITYQ2

Abstract

Aim and Background: Gastro-intestinal cancers are the most common kind of cancers all over the world. They are multifactorial disease and both genetical and environmental factors are involved in their progression. Adenocarcinoma is the most common type of stomach cancers. BREVININ-2R is a novel antimicrobial and anticancer peptide that is isolated from the skin secretions of a family of frogs called Rana. The 25-amino acid long peptide shows anticancer activity and induces antimicrobial activity. BREVININ-2R is a 25 amino acid long cationic peptide that shows very low hemolytic activity against red blood cells. In this paper we study cytotoxicity of BREVININ-2R onto AGS cell line.Materials and methods: AGS cell line was incubated with different concentrations of peptide during different periods of time, CYTOTOXICITY OF PEPTIDE and VIABILITY of AGS cell line was assessed by MTT-assay. The experiment was repeated three times and the average VIABILITY values were calculated.Results: Our findings show that VIABILITY of treated cells decreased consistently with increasing concentrations within the periods of time.Conclusion: Because of low hemolytic activity, BREVININ-2R is a good specimen in drug designing. BREVININ-2R triggers cell death by means of activation of autophagy and shows anticancer activity against AGS malignant cell lines.

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APA: Copy

HASANVAND JAMADI, ROBAB, ASADI, ASADOLLAH, & HASANVAND JAMADI, MEHDI. (2013). IN VITRO EVALUATION OF ANTICANCER ACTIVITY OF BREVININ-2R AGAINST AGS CELL LINE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 3(12), 107-110. SID. https://sid.ir/paper/204687/en

Vancouver: Copy

HASANVAND JAMADI ROBAB, ASADI ASADOLLAH, HASANVAND JAMADI MEHDI. IN VITRO EVALUATION OF ANTICANCER ACTIVITY OF BREVININ-2R AGAINST AGS CELL LINE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2013;3(12):107-110. Available from: https://sid.ir/paper/204687/en

IEEE: Copy

ROBAB HASANVAND JAMADI, ASADOLLAH ASADI, and MEHDI HASANVAND JAMADI, “IN VITRO EVALUATION OF ANTICANCER ACTIVITY OF BREVININ-2R AGAINST AGS CELL LINE,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 3, no. 12, pp. 107–110, 2013, [Online]. Available: https://sid.ir/paper/204687/en

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