CYTOTOXICITY EFFECT OF BREVININ-2R PEPTIDE ON ORAL SQUAMOUS CELL CARCINOMA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHAZIMEH F.; GOLESTAN NEZHAD Z.; BAKHTARI A.; BAKHSHI M.; YOUSEF SHAHI H.; GAVANJI SH.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Advances in Medical and Biomedical Research Year:2017 | Volume:24 | Issue:107 Page(s): 39-48

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

770

Download:

Cites:

Information Journal Paper

Title

CYTOTOXICITY EFFECT OF BREVININ-2R PEPTIDE ON ORAL SQUAMOUS CELL CARCINOMA

Author(s)

Keywords

BREVININ-2RQ1

CELL CYTOTOXICQ1

ORAL SQUAMOUS CELL CARCINOMAQ1

MEDICAL PEPTIDEQ1

Abstract

Background and Objective: Peptide as an agent in manufacturing new drugs has recently been taken into consideration. BREVININ-2R is a nano peptide with a wide range of biological actions. Thus, the current study was designed in order to evaluate the in vitro effects of BREVININ-2R on ORAL SQUAMOUS CELL CARCINOMA cells in comparison to normal mice fibroblast cells.Materials and Methods: In this study, ORAL SQUAMOUS CELL CARCINOMA cells (KB) and normal mice fibroblast cells (L929) were cultured and treated with different concentrations of BREVININ-2R (0.1-30 mg/ml) for 24, 48 and 72 hours. Then, cell viability was calculated by MTT method. Data were fed to SPSS software (version 20) via which One Way ANOVA and Tukey tests was calculated for the collected data.Results: The half-maximal inhibitory concentration (IC50) of BREVININ-2R for KB cells and L929 cells were 15.48 and 24.14 mg/ml respectively, demonstrating that higher concentration of BREVININ-2R is necessary in order to reach IC50 concentration for L929 cells (about 1.5 times).Conclusion: Results point out that BREVININ-2R peptide is more effective on ORAL SQUAMOUS CELL CARCINOMA cells compared to normal mice fibroblast cells (L929).

Cites

No record.

References

No record.

Cite

APA: Copy

KHAZIMEH, F., GOLESTAN NEZHAD, Z., BAKHTARI, A., BAKHSHI, M., YOUSEF SHAHI, H., & GAVANJI, SH.. (2017). CYTOTOXICITY EFFECT OF BREVININ-2R PEPTIDE ON ORAL SQUAMOUS CELL CARCINOMA. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 24(107), 39-48. SID. https://sid.ir/paper/61276/en

Vancouver: Copy

KHAZIMEH F., GOLESTAN NEZHAD Z., BAKHTARI A., BAKHSHI M., YOUSEF SHAHI H., GAVANJI SH.. CYTOTOXICITY EFFECT OF BREVININ-2R PEPTIDE ON ORAL SQUAMOUS CELL CARCINOMA. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2017;24(107):39-48. Available from: https://sid.ir/paper/61276/en

IEEE: Copy

F. KHAZIMEH, Z. GOLESTAN NEZHAD, A. BAKHTARI, M. BAKHSHI, H. YOUSEF SHAHI, and SH. GAVANJI, “CYTOTOXICITY EFFECT OF BREVININ-2R PEPTIDE ON ORAL SQUAMOUS CELL CARCINOMA,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 24, no. 107, pp. 39–48, 2017, [Online]. Available: https://sid.ir/paper/61276/en

Related Journal Papers