Vincristine loaded niosomes as an effective drug delivery system for lymphoma

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Mehrabi -; Chiani -; Norouzian -; Shokrgozar -; Amanzadeh -; Toliyat -; AKBARZADEH -

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2019 | Volume:9 | Issue:34 Page(s): 65-73

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

914

Download:

Cites:

Information Journal Paper

Title

Vincristine loaded niosomes as an effective drug delivery system for lymphoma

Author(s)

Keywords

NiosomesQ1

VincristineQ1

Controlled releaseQ2

CytotoxicityQ2

Raji Cell LineQ1

Abstract

Aim and Background: Vincristine is a herbal anticancer drug which is used to treat a wide range of cancers such as lymphoma. Niosomes are important drug carriers. The aim of this study was to prepare PEGylated niosomal form of Vincristine in order to increase its efficacy in lymph nodes’ cancer. Material and Methods: PEGylated niosomal Vincristine (PEG-nVCR) was prepared by thin film hydration method. Physicochemical properties of niosomal formulation, such as size, zeta potential, encapsulation efficacy, release rate, stability and Cytotoxicity were studied. Mean size and zeta potential was measured by dynamic light scattering. Releasing rate of drug from Niosomes was determined by dialysis diffusion method. Cytotoxicity study was evaluated by MTT assay. Results: mean particle size and zeta potential was obtained about 118. 1± 2. 3 nm and-21. 5± 1. 2 mV, respectively. The cytotoxic effect of PEG-nVCR against Raji cells was significantly higher than of free drug. Stability study indicated that PEG-nVCR was stable for at least two months. Release of drug from PEG-nVCR formulation showed a sustained release pattern, while the free drug release rate reached to 100 % less than 6 hours. Conclusion: our findings demonstrated that the use of Niosomes as a drug carrier plays an important role in anticancer efficacy of Vincristine and can be considered as an alternative to conventional form.

Cites

No record.

References

No record.

Cite

APA: Copy

Mehrabi, -, Chiani, -, Norouzian, -, Shokrgozar, -, Amanzadeh, -, Toliyat, -, & AKBARZADEH, -. (2019). Vincristine loaded niosomes as an effective drug delivery system for lymphoma. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 9(34 ), 65-73. SID. https://sid.ir/paper/204720/en

Vancouver: Copy

Mehrabi -, Chiani -, Norouzian -, Shokrgozar -, Amanzadeh -, Toliyat -, AKBARZADEH -. Vincristine loaded niosomes as an effective drug delivery system for lymphoma. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2019;9(34 ):65-73. Available from: https://sid.ir/paper/204720/en

IEEE: Copy

- Mehrabi, - Chiani, - Norouzian, - Shokrgozar, - Amanzadeh, - Toliyat, and - AKBARZADEH, “Vincristine loaded niosomes as an effective drug delivery system for lymphoma,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 9, no. 34 , pp. 65–73, 2019, [Online]. Available: https://sid.ir/paper/204720/en

Related Journal Papers