THE EFFECT OF SALVIA OFFICINALIS HYDROALCOHOLIC EXTRACT ON PTZ-INDUCED SEIZURE THRESHOLD IN VINCRISTINE INJECTED MICE

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NAMVARAN ABBASABAD A.; TAVAKKOLI GHAZANI F.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2012 | Volume:13 | Issue:6 Page(s): 47-55

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Title

THE EFFECT OF SALVIA OFFICINALIS HYDROALCOHOLIC EXTRACT ON PTZ-INDUCED SEIZURE THRESHOLD IN VINCRISTINE INJECTED MICE

Author(s)

NAMVARAN ABBASABAD A. | TAVAKKOLI GHAZANI F. | Issue Writer Certificate

Keywords

SALVIA OFFICINALISQ2

VINCRISTINEQ3

PENTYLENETETRAZOLEQ2

SEIZUREQ3

Abstract

Background and aims: Studies show that VINCRISTINE is an anti-cancer drug which has neuropathic effects. Some studies have shown that SALVIA OFFICINALIS has therapeutic effects on nervous system. The purpose of this study was to investigate the effects of SALVIA OFFICINALIS hydroalcoholic extract and VINCRISTINE on PENTYLENETETRAZOLE (PTZ) -induced SEIZURE threshould in mice.Methods: In this experimental study, 32 mice were randomly divided into 4 groups. The first group received normal saline, second group received SALVIA OFFICINALIS hydroalcoholic extract (1 g/kg, i.p.), third group received VINCRISTINE (10 mg/kg/day, i.v.) and finally the fourth group received hydroalcoholic extract of SALVIA OFFICINALIS plus VINCRISTINE. Then the SEIZURE threshold was determined for each group after the injections. The data were analyzed using one way ANOVA followed by Tukey test.Results: The results of this study showed that hydroalcoholic extract of SALVIA OFFICINALIS significantly increased the PTZ Induced SEIZURE threshold (P<0.05). Simultaneous uses of VINCRISTINE and SALVIA OFFICINALIS extract caused a significant increase in SEIZURE threshold in VINCRISTINE group (P<0.05).Conclusion: Considering the existence of different types of ingredients in SALVIA OFFICINALIS extract; such as antioxidants, b-pinene and spathulenol, which have beneficial affects on the nervous system as well as their antioxidant effects, we can use this plant to reduce VINCRISTINE induced neuropathic effects.

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APA: Copy

NAMVARAN ABBASABAD, A., & TAVAKKOLI GHAZANI, F.. (2012). THE EFFECT OF SALVIA OFFICINALIS HYDROALCOHOLIC EXTRACT ON PTZ-INDUCED SEIZURE THRESHOLD IN VINCRISTINE INJECTED MICE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 13(6), 47-55. SID. https://sid.ir/paper/58721/en

Vancouver: Copy

NAMVARAN ABBASABAD A., TAVAKKOLI GHAZANI F.. THE EFFECT OF SALVIA OFFICINALIS HYDROALCOHOLIC EXTRACT ON PTZ-INDUCED SEIZURE THRESHOLD IN VINCRISTINE INJECTED MICE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;13(6):47-55. Available from: https://sid.ir/paper/58721/en

IEEE: Copy

A. NAMVARAN ABBASABAD, and F. TAVAKKOLI GHAZANI, “THE EFFECT OF SALVIA OFFICINALIS HYDROALCOHOLIC EXTRACT ON PTZ-INDUCED SEIZURE THRESHOLD IN VINCRISTINE INJECTED MICE,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 13, no. 6, pp. 47–55, 2012, [Online]. Available: https://sid.ir/paper/58721/en

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