The Effect of Hydroalcoholic Extract of Glaucium flavum on Serum Level of TSH in Alloxan Induced Diabetic Rats

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BANESHI ALI REZA; Nowroozi asl Ardavan; Darya Gholam Hossein; Mosavi Seyyedeh Maryam

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Journal: JOURNAL OF ANIMAL ENVIRONMENT Year:2020 | Volume:11 | Issue:4 Page(s): 77-82

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Title

The Effect of Hydroalcoholic Extract of Glaucium flavum on Serum Level of TSH in Alloxan Induced Diabetic Rats

Author(s)

BANESHI ALI REZA | Nowroozi asl Ardavan | Darya Gholam Hossein | Mosavi Seyyedeh Maryam | Issue Writer Certificate

Keywords

Diabetes MellitusQ1

Glaucium flavumQ1

TSHQ1

AlloxanQ1

RatQ2

Abstract

Disordered TSH secretion from pituitary gland has always been one of the controversial complications of diabetes. This study was conducted to evaluate the effect of oral administRation of G. flavum on serum level of TSH in healthy and diabetic male Rats. In this experimental study, 56 adult male Wistar Rats were randomly divided into 7 groups of 8 including: healthy control, healthy treated with 250 and 500 mg/kg of G. flavum extract, diabetic control, diabetic treated with 250 and 500 mg/kg of the extract, and 5 µ g/kg doses of Glibenclamide. Diabetes was induced by single injection of Alloxan. After 30 days, blood samples were collected and TSH levels were measured. Finally, the data were analyzed using one-way ANOVA. Results declare that, the mean of diabetic+250 group was significantly higher than diabetic control group (P<0. 001); Also, the mean in diabetic+500 and diabetic+drug groups did not have a significant different with control group (P>0. 05). In conclusion, The G. flavum extract have been able to increase the level of TSH in diabetic Rats, somehow that the higher dose can improve the complication, as equal as healthy control group.

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APA: Copy

BANESHI, ALI REZA, Nowroozi asl, Ardavan, Darya, Gholam Hossein, & Mosavi, Seyyedeh Maryam. (2020). The Effect of Hydroalcoholic Extract of Glaucium flavum on Serum Level of TSH in Alloxan Induced Diabetic Rats. JOURNAL OF ANIMAL ENVIRONMENT, 11(4 ), 77-82. SID. https://sid.ir/paper/206572/en

Vancouver: Copy

BANESHI ALI REZA, Nowroozi asl Ardavan, Darya Gholam Hossein, Mosavi Seyyedeh Maryam. The Effect of Hydroalcoholic Extract of Glaucium flavum on Serum Level of TSH in Alloxan Induced Diabetic Rats. JOURNAL OF ANIMAL ENVIRONMENT[Internet]. 2020;11(4 ):77-82. Available from: https://sid.ir/paper/206572/en

IEEE: Copy

ALI REZA BANESHI, Ardavan Nowroozi asl, Gholam Hossein Darya, and Seyyedeh Maryam Mosavi, “The Effect of Hydroalcoholic Extract of Glaucium flavum on Serum Level of TSH in Alloxan Induced Diabetic Rats,” JOURNAL OF ANIMAL ENVIRONMENT, vol. 11, no. 4 , pp. 77–82, 2020, [Online]. Available: https://sid.ir/paper/206572/en

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