MUTATIONS IN THE β-CATENINGENE IN GASTRIC AND ESOPHAGEAL CANCERS: AN ANALYSIS IN IRANIAN PATIENTS

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TAFRIHI M.; MOHAMMADZADEH ROGHAYEH; JAHANZAD I.; ARAB NAJAFI S.M.

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Paper Information

Journal: JOURNAL OF SCIENCE (UNIVERSITY OF TEHRAN) (JSUT) Year:2007 | Volume:32 | Issue:4 (SECTION: BIOLOGY 2) Page(s): 161-167

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Title

MUTATIONS IN THE β-CATENINGENE IN GASTRIC AND ESOPHAGEAL CANCERS: AN ANALYSIS IN IRANIAN PATIENTS

Author(s)

TAFRIHI M. | MOHAMMADZADEH ROGHAYEH | JAHANZAD I. | ARAB NAJAFI S.M. | Issue Writer Certificate

Keywords

GASTRIC CANCERQ3

ESOPHAGEAL CANCERQ3

β-CATENINQ3

EXON 3Q3

Abstract

Deregulation of Wnt signal transduction through the mutations to several components of this pathway, like adenomatous polyposis coli (APC) and b-catenin, has been reported in various tumor types. Here from 40 paraffin-embedded gastric adenocarcinoma and 50 paraffin-embedded esophageal squamous cell carcinoma tumor samples, genomic DNA was extracted and used as template for PCR amplification of EXON 3 of the b-catenin gene (CTNNBI).By sequencing analysis of the PCR products, we detected five (12.5%) somatic missense mutations in gastric adenocarcinoma samples which three occurring at the regulatory GSK-3b phosphorylation sites. The other two mutations were adjacent to the phosphorylation sites. Among esophageal tumor samples, two (4.0%) had a missense mutation at codon 40 (a threonine), changing it to a glycine in one sample (T40G) and to an alanine in the other (T40A). We conclude that among Iranian patients, disruption of b-Catenin activity might play an important role in the development of a subset of gastric and a smaller subset of ESOPHAGEAL CANCERs.

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APA: Copy

TAFRIHI, M., MOHAMMADZADEH, ROGHAYEH, JAHANZAD, I., & ARAB NAJAFI, S.M.. (2007). MUTATIONS IN THE β-CATENINGENE IN GASTRIC AND ESOPHAGEAL CANCERS: AN ANALYSIS IN IRANIAN PATIENTS. JOURNAL OF SCIENCE (UNIVERSITY OF TEHRAN) (JSUT), 32(4 (SECTION: BIOLOGY 2)), 161-167. SID. https://sid.ir/paper/2070/en

Vancouver: Copy

TAFRIHI M., MOHAMMADZADEH ROGHAYEH, JAHANZAD I., ARAB NAJAFI S.M.. MUTATIONS IN THE β-CATENINGENE IN GASTRIC AND ESOPHAGEAL CANCERS: AN ANALYSIS IN IRANIAN PATIENTS. JOURNAL OF SCIENCE (UNIVERSITY OF TEHRAN) (JSUT)[Internet]. 2007;32(4 (SECTION: BIOLOGY 2)):161-167. Available from: https://sid.ir/paper/2070/en

IEEE: Copy

M. TAFRIHI, ROGHAYEH MOHAMMADZADEH, I. JAHANZAD, and S.M. ARAB NAJAFI, “MUTATIONS IN THE β-CATENINGENE IN GASTRIC AND ESOPHAGEAL CANCERS: AN ANALYSIS IN IRANIAN PATIENTS,” JOURNAL OF SCIENCE (UNIVERSITY OF TEHRAN) (JSUT), vol. 32, no. 4 (SECTION: BIOLOGY 2), pp. 161–167, 2007, [Online]. Available: https://sid.ir/paper/2070/en

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