CONTROLLED ANTIBIOTIC DELIVERY BY GELATIN NANOSPHERES: OPTIMIZATION, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION

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Fathollahipour Shahrzad; Ghaee Azadeh; ABOUEI MEHRIZI ALI; Koosha Mojtaba

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Journal: JOURNAL OF NANOSTRUCTURES Year:2016 | Volume:6 | Issue:4 Page(s): 285-292

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Title

CONTROLLED ANTIBIOTIC DELIVERY BY GELATIN NANOSPHERES: OPTIMIZATION, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION

Author(s)

Fathollahipour Shahrzad | Ghaee Azadeh | ABOUEI MEHRIZI ALI | Koosha Mojtaba | Issue Writer Certificate

Keywords

GELATIN NANOPARTICLESQ2

NANOPRECIPITATIONQ2

PLURONIC BASED DELIVERY SYSTEMSQ1

DRUG RELEASEQ1

ANTIBACTERIALQ1

Abstract

The present work focuses on preparation and characterization of erythromycin loaded GELATIN NANOPARTICLES through NANOPRECIPITATION method. The procedure consists of the addition of the aqueous gelatin solution to the non-solvent phase containing Lutherol F127. Three different measures of cross-linker and polymer concentration were also examined, and the optimum concentration was found. The morphology of GELATIN NANOPARTICLES was characterized by field emission scanning electron microscope. It was shown that the optimal morphology can be achieved at the concentration of 1.25 wt % of gelatin in aqueous phase by addition of 20 mL of glutaraldehyde 5%, as the crosslinking agent. Nanoparticle wet size determination was carried out using a dynamic light scattering system and found to be approximately 100 nm. Furthermore, Erythromycin release studies proved the suitability of these particles as a drug delivery system, at least in the studied 72 hours interval. As suggested by related measurements, these nanoparticles are good candidates for ANTIBACTERIAL agent release in any possible related application.

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APA: Copy

Fathollahipour, Shahrzad, Ghaee, Azadeh, ABOUEI MEHRIZI, ALI, & Koosha, Mojtaba. (2016). CONTROLLED ANTIBIOTIC DELIVERY BY GELATIN NANOSPHERES: OPTIMIZATION, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION. JOURNAL OF NANOSTRUCTURES, 6(4), 285-292. SID. https://sid.ir/paper/211000/en

Vancouver: Copy

Fathollahipour Shahrzad, Ghaee Azadeh, ABOUEI MEHRIZI ALI, Koosha Mojtaba. CONTROLLED ANTIBIOTIC DELIVERY BY GELATIN NANOSPHERES: OPTIMIZATION, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION. JOURNAL OF NANOSTRUCTURES[Internet]. 2016;6(4):285-292. Available from: https://sid.ir/paper/211000/en

IEEE: Copy

Shahrzad Fathollahipour, Azadeh Ghaee, ALI ABOUEI MEHRIZI, and Mojtaba Koosha, “CONTROLLED ANTIBIOTIC DELIVERY BY GELATIN NANOSPHERES: OPTIMIZATION, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION,” JOURNAL OF NANOSTRUCTURES, vol. 6, no. 4, pp. 285–292, 2016, [Online]. Available: https://sid.ir/paper/211000/en

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