ROLES OF THE RECQL4A GENE IN THE REPAIR OF DNA DAMAGES CAUSED BY METHYL METHANESULFONATE IN ARABIDOPSIS SEEDS AND SEEDLINGS

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BAGHERIEH NAJAR M.B.; NAVABPOUR S.

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Journal: IRANIAN JOURNAL OF BIOLOGY Year:2008 | Volume:21 | Issue:2 Page(s): 175-183

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Title

ROLES OF THE RECQL4A GENE IN THE REPAIR OF DNA DAMAGES CAUSED BY METHYL METHANESULFONATE IN ARABIDOPSIS SEEDS AND SEEDLINGS

Author(s)

BAGHERIEH NAJAR M.B. | NAVABPOUR S. | Issue Writer Certificate

Keywords

ARABIDOPSISQ3

RECQQ3

DNA HELICASEQ3

DNA RECOMBINATIONQ3

Abstract

Proteins belong to the RECQ family found in prokaryotes and eukaryotes have a central domain with seven conserved motifs which perform DNA HELICASE activity. Members of the family in E.coli, yeast and human have been shown to be involved in DNA repair, recombination, transcription and replication. Recently the completion of the whole genome sequence of the model plant ARABIDOPSIS thaliana allowed for identification of seven putative RECQ homologues. We already showed that RECQl4A is involved in plant responses to DNA damage and the regulation of DNA RECOMBINATION. Here, an evolutionary comparison between the RECQl4A protein and other RECQ family members is shown. In addition, the roles that RECQl4A plays in the repair of DNA damage caused by methyl methanesulfonate MMS in seed germination and seedlings growth are uncovered. A phylogenetic analysis revealed that ARABIDOPSIS RECQl4A and RECQl4B have evolved from a recent duplication but others are more distantly related, suggesting that multiple RECQ genes were present in the last common ancestor of plants and animals. Results obtained from analysis of three independent T-DNA mutants showed RECQl4A mutant seedlings are hypersensitive to increasing concentrations of MMS, as compared to wild type. However, no phenotypic differences between the wild type and mutant germinating seeds were observed when seeds grown on medium containing MMS. These suggest that RECQl4A may play various roles in DNA repair in different developmental stages of ARABIDOPSIS growth. Unraveling the exact roles that RECQl4A plays in DNA repair and recombination may allow for developing new tools for gene targeting in plants.

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APA: Copy

BAGHERIEH NAJAR, M.B., & NAVABPOUR, S.. (2008). ROLES OF THE RECQL4A GENE IN THE REPAIR OF DNA DAMAGES CAUSED BY METHYL METHANESULFONATE IN ARABIDOPSIS SEEDS AND SEEDLINGS. IRANIAN JOURNAL OF BIOLOGY, 21(2), 175-183. SID. https://sid.ir/paper/21264/en

Vancouver: Copy

BAGHERIEH NAJAR M.B., NAVABPOUR S.. ROLES OF THE RECQL4A GENE IN THE REPAIR OF DNA DAMAGES CAUSED BY METHYL METHANESULFONATE IN ARABIDOPSIS SEEDS AND SEEDLINGS. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2008;21(2):175-183. Available from: https://sid.ir/paper/21264/en

IEEE: Copy

M.B. BAGHERIEH NAJAR, and S. NAVABPOUR, “ROLES OF THE RECQL4A GENE IN THE REPAIR OF DNA DAMAGES CAUSED BY METHYL METHANESULFONATE IN ARABIDOPSIS SEEDS AND SEEDLINGS,” IRANIAN JOURNAL OF BIOLOGY, vol. 21, no. 2, pp. 175–183, 2008, [Online]. Available: https://sid.ir/paper/21264/en

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