SOLID PHASE CHEMICAL SYNTHESIS AND STRUCTURE- ACTIVITY STUDY OF BREVININ-2R AND ANALOGUES AS ANTIMICROBIAL PEPTIDES

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YAGHOUBI H.; NADERIMANESH H.; OMIDI Y.; ASOODEH A.

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Journal: IRANIAN JOURNAL OF BIOLOGY Year:2012 | Volume:25 | Issue:3 Page(s): 366-376

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Information Journal Paper

Title

SOLID PHASE CHEMICAL SYNTHESIS AND STRUCTURE- ACTIVITY STUDY OF BREVININ-2R AND ANALOGUES AS ANTIMICROBIAL PEPTIDES

Author(s)

YAGHOUBI H. | NADERIMANESH H. | OMIDI Y. | ASOODEH A. | Issue Writer Certificate

Keywords

BREVININ-2RQ2

ANTIMICROBIAL PEPTIDEQ2

SECONDARY STRUCTUREQ2

HEMOLYTIC ACTIVITYQ2

Abstract

BREVININ-2R, consisting of 25 amino acid residues, from the skin of the frog Rana ridibunda has potent antimicrobial and low HEMOLYTIC ACTIVITY. From a structural point of view, this peptide has an N-terminal hydrophilic region, and a C-terminal loop region delineated by an intra-disulfide bridge, which is a common structural feature of ANTIMICROBIAL PEPTIDEs from Rana species. To investigate the structural features for antimicrobial, HEMOLYTIC ACTIVITY and proteolytic stability, analogues diastereomer Sami-D BREVININ-2R were synthesized and characterized. Structure-activity relationship studies revealed the importance of the amphipathic a-helical conformation of the reported peptides in inducing antimicrobial effects. Analogues D shows lower antimicrobial activity than BREVININ-2R and did not show any HEMOLYTIC ACTIVITY up 400mg/ml whereas the BREVININ-2R show low HEMOLYTIC ACTIVITY. Circular dichroism spectra and the retention time on the C18 reverse phase column revealed that the BREVININ-2R formed an amphipathic loop which increased hydrophobicity and helped to induce theα-helical structure in the membrane-mimetic environment. The HEMOLYTIC ACTIVITY of BREVININ-2R and its analogs also correlated well with the retention time and the a-helicity.

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APA: Copy

YAGHOUBI, H., NADERIMANESH, H., OMIDI, Y., & ASOODEH, A.. (2012). SOLID PHASE CHEMICAL SYNTHESIS AND STRUCTURE- ACTIVITY STUDY OF BREVININ-2R AND ANALOGUES AS ANTIMICROBIAL PEPTIDES. IRANIAN JOURNAL OF BIOLOGY, 25(3), 366-376. SID. https://sid.ir/paper/21451/en

Vancouver: Copy

YAGHOUBI H., NADERIMANESH H., OMIDI Y., ASOODEH A.. SOLID PHASE CHEMICAL SYNTHESIS AND STRUCTURE- ACTIVITY STUDY OF BREVININ-2R AND ANALOGUES AS ANTIMICROBIAL PEPTIDES. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2012;25(3):366-376. Available from: https://sid.ir/paper/21451/en

IEEE: Copy

H. YAGHOUBI, H. NADERIMANESH, Y. OMIDI, and A. ASOODEH, “SOLID PHASE CHEMICAL SYNTHESIS AND STRUCTURE- ACTIVITY STUDY OF BREVININ-2R AND ANALOGUES AS ANTIMICROBIAL PEPTIDES,” IRANIAN JOURNAL OF BIOLOGY, vol. 25, no. 3, pp. 366–376, 2012, [Online]. Available: https://sid.ir/paper/21451/en

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