SYNTHESIS OF (1-H) PYRAZOLO [4, 5-B] QUINOXALINE AS POTENTIAL ANTI-MICROBIAL AGENT

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ARBABI AVISHAN; BEKHRADNIA AHMADREZA; MORTEZA SEMNANI KATAYOUN; AHMADIAN MOGHADAM MARYAM; GHANBARI ZAHRA

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:27 | Issue:156 Page(s): 28-37

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Title

SYNTHESIS OF (1-H) PYRAZOLO [4, 5-B] QUINOXALINE AS POTENTIAL ANTI-MICROBIAL AGENT

Author(s)

Keywords

QUINOXALINE DERIVATIVESQ1

FLAVOZOLEQ1

ANTIMICROBIAL EFFECTSQ1

ANTICANCER EFFECTSQ1

4-AMINOANTIPYRINEQ1

Abstract

Background and purpose: Increasing resistance of microbes to antimicrobial drugs necessitatesthe production of new compounds of more extensive activity together with low toxicity. Compoundscontaining quinoxaline and pyrazole cycles comprise important group of nitrogen-bearing heterocycliccompounds. These scaffolds possess a wide spectrum of biological effects including antimicrobial andanticancer effects. Materials and methods: Three steps procedure were designed to prepare the title compound. 3-(glycerol-1-yl)-1-phenyl flavazole was prepared by adding D-glucose, and ortho-phenylenediamine tophenylhydrazine in presence of acetic acid. Then, the desired aldehyde was obtained by adding sodiumperiodate to the solution. Finally, adding 4-AMINOANTIPYRINE gave the target product. Results: The considered imine compound was synthesized and its structure was confirmed usingNMR, IR, and GC-Mass spectroscopy techniques. Conclusion: In this study, (1-H) pyrazolo [4, 5-b] quinoxaline was prepared using inexpensiveand widely available materials. In present research, not only the reaction performance was improved, butalso some time and resource savings along with enhanced efficiency were achieved. The methodproposed is an efficient, simple, and fast method to synthesize the aforementioned compound withantibacterial potential.

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APA: Copy

ARBABI, AVISHAN, BEKHRADNIA, AHMADREZA, MORTEZA SEMNANI, KATAYOUN, AHMADIAN MOGHADAM, MARYAM, & GHANBARI, ZAHRA. (2018). SYNTHESIS OF (1-H) PYRAZOLO [4, 5-B] QUINOXALINE AS POTENTIAL ANTI-MICROBIAL AGENT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(156 ), 28-37. SID. https://sid.ir/paper/44724/en

Vancouver: Copy

ARBABI AVISHAN, BEKHRADNIA AHMADREZA, MORTEZA SEMNANI KATAYOUN, AHMADIAN MOGHADAM MARYAM, GHANBARI ZAHRA. SYNTHESIS OF (1-H) PYRAZOLO [4, 5-B] QUINOXALINE AS POTENTIAL ANTI-MICROBIAL AGENT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;27(156 ):28-37. Available from: https://sid.ir/paper/44724/en

IEEE: Copy

AVISHAN ARBABI, AHMADREZA BEKHRADNIA, KATAYOUN MORTEZA SEMNANI, MARYAM AHMADIAN MOGHADAM, and ZAHRA GHANBARI, “SYNTHESIS OF (1-H) PYRAZOLO [4, 5-B] QUINOXALINE AS POTENTIAL ANTI-MICROBIAL AGENT,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 156 , pp. 28–37, 2018, [Online]. Available: https://sid.ir/paper/44724/en

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