FORCED SWIM STRESS EFFECTS ON PENTYLENETETRAZOLE INDUCED SEIZURE IN RAT

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TAKHTY T.; FEREIDONI M.; MOGHIMI A.; BEHNAM RASOULI M.

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Journal: IRANIAN JOURNAL OF BIOLOGY Year:2012 | Volume:25 | Issue:3 Page(s): 377-388

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Title

FORCED SWIM STRESS EFFECTS ON PENTYLENETETRAZOLE INDUCED SEIZURE IN RAT

Author(s)

TAKHTY T. | FEREIDONI M. | MOGHIMI A. | BEHNAM RASOULI M. | Issue Writer Certificate

Keywords

SWIM STRESSQ2

PENTYLENETETRAZOLEQ2

EPILEPSYQ2

SEIZUREQ2

Abstract

Introduction: Stress effects on EPILEPSY excite different dissections. To clarify more, we studied the influences of acute and repeated stress on convulsions EPILEPSY elicited by PENTYLENETETRAZOLE (PTZ).Methods: Adult male Wistar rats (200-250g, 10≥n≤7) were used. Two PTZ control groups, first with one session of injection (45 mg/Kg PTZ i.p.) and second with 3 session of injection (25 mg/Kg PTZ, with 15 minute interval) and two sham groups with vehicle (saline) injection instead of PTZ were used in this study. Three experimental categories, each one contain the above groups of PTZ were designed, animals in the first categories expose to forced SWIM STRESS 30 min before PTZ treatments. Treating of PTZ was done for the second categories 24 h after swimming and for third one 24 h after 3rd sessions of swimming (24h interval between each session), after PTZ treatments the EPILEPSY behaviors were recorded.Results: Forced swimming 30 min before one session of PTZ, reduced SEIZURE (P<0.05) 5 min after PTZ injection, SWIM STRESS 24 min before one session of PTZ, reduced SEIZURE (P<0.01) during 10-15 min after PTZ injection. In one session of PTZ treating, 24h after repeated SWIM STRESS, reduced SEIZURE during 5 (P<0.01) and 10-15 min (P<0.01) after PTZ injection was observed. Forced swimming 30 min before three session of PTZ, increased SEIZURE 5-10 (P<0.01) and 25-30 min (P<0.05) after PTZ injection, SWIM STRESS 24 min before three session of PTZ, reduced SEIZURE (P<0.05) during 15- 25 min after PTZ injection. In three session of PTZ treating, 24h after repeated SWIM STRESS, reduced SEIZURE during 15-25 (P<0.05) after PTZ injection was observed. Conclusions: Stress elicited both exciting and inhibitory effects on PTZ induced SEIZURE. If it supposes that PTZ (45 mg/kg) saturates excitatory effects, so the inhibitory effects remains for stress, but PTZ (25 mg/Kg) has little influence on nervous system for revealing EPILEPSY, thus exciting part of stress can add to functions of PTZ and strength its effects. It may that repeated stress ability for recruitment of compensatory systems which regulates increased neurons excitation, at least in part, is responsible for inhibitory effect of repeated stress on PTZ induced SEIZURE.

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APA: Copy

TAKHTY, T., FEREIDONI, M., MOGHIMI, A., & BEHNAM RASOULI, M.. (2012). FORCED SWIM STRESS EFFECTS ON PENTYLENETETRAZOLE INDUCED SEIZURE IN RAT. IRANIAN JOURNAL OF BIOLOGY, 25(3), 377-388. SID. https://sid.ir/paper/21457/en

Vancouver: Copy

TAKHTY T., FEREIDONI M., MOGHIMI A., BEHNAM RASOULI M.. FORCED SWIM STRESS EFFECTS ON PENTYLENETETRAZOLE INDUCED SEIZURE IN RAT. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2012;25(3):377-388. Available from: https://sid.ir/paper/21457/en

IEEE: Copy

T. TAKHTY, M. FEREIDONI, A. MOGHIMI, and M. BEHNAM RASOULI, “FORCED SWIM STRESS EFFECTS ON PENTYLENETETRAZOLE INDUCED SEIZURE IN RAT,” IRANIAN JOURNAL OF BIOLOGY, vol. 25, no. 3, pp. 377–388, 2012, [Online]. Available: https://sid.ir/paper/21457/en

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