ASSESSMENT OF AQUEOUS EXTRACT OF HUMULUS LUPULUS EFFECTS ON SEIZURE INDUCED BY INTRAPERITONEAL INJECTION OF PENTYLENETETRAZOLE IN MICE

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Namvar Aghdash Simin; Nasirifard Soheila

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Journal: Neuroscience Journal of Shefaye Khatam Year:2015 | Volume:3 | Issue:2 Page(s): 49-54

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Title

ASSESSMENT OF AQUEOUS EXTRACT OF HUMULUS LUPULUS EFFECTS ON SEIZURE INDUCED BY INTRAPERITONEAL INJECTION OF PENTYLENETETRAZOLE IN MICE

Author(s)

Namvar Aghdash Simin | Nasirifard Soheila | Issue Writer Certificate

Keywords

SEIZURESQ2

EPILEPSYQ2

PENTYLENETETRAZOLEQ3

Abstract

Introduction: EPILEPSY is one of the most common disorders of the brain, affecting at least 50 million persons worldwide. Despite a variety of current antiepileptic drugs, research for discovering new drugs with more efficacies and less side effects has been continued. Herbal medicine has various natural substances and proper context for this type of research. The aim of this study was to investigate the effect ofHumulus lupulus (Hops) extract on seizure attacks in an experimental animal model.Materials and Methods: 40 male mice have been chosen randomly and divided into 5 groups; including control group, sham group, and three experimental groups. Treated mice received aqueous extract ofHumulus lupulus via gavage at doses of 200, 400, and 600 mg/kg for 4 weeks. Thirty minutes after gavage with different doses of the herb or distilled water (sham mice), PENTYLENETETRAZOLE (PTZ; 45mg/kg) was injected intraperitoneally. Animals immediately transferred to a special cage and the seizure behaviors were recorded by a camera during a 25 minutes period.Results: Data analysis indicated that the aqueous extract of Humulus lupulus had a significant inhibitory effect on PTZ-induced seizure. Treatment withHumulus lupulus significantly increased the latency of seizure onset, decreased the intensity of seizure, and seizure duration.Conclusion: The attained results showed that Hops extract has anticonvulsant effect on PTZ-induced seizure and may be useful for treatment of EPILEPSY.

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APA: Copy

Namvar Aghdash, Simin, & Nasirifard, Soheila. (2015). ASSESSMENT OF AQUEOUS EXTRACT OF HUMULUS LUPULUS EFFECTS ON SEIZURE INDUCED BY INTRAPERITONEAL INJECTION OF PENTYLENETETRAZOLE IN MICE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 3(2), 49-54. SID. https://sid.ir/paper/258028/en

Vancouver: Copy

Namvar Aghdash Simin, Nasirifard Soheila. ASSESSMENT OF AQUEOUS EXTRACT OF HUMULUS LUPULUS EFFECTS ON SEIZURE INDUCED BY INTRAPERITONEAL INJECTION OF PENTYLENETETRAZOLE IN MICE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2015;3(2):49-54. Available from: https://sid.ir/paper/258028/en

IEEE: Copy

Simin Namvar Aghdash, and Soheila Nasirifard, “ASSESSMENT OF AQUEOUS EXTRACT OF HUMULUS LUPULUS EFFECTS ON SEIZURE INDUCED BY INTRAPERITONEAL INJECTION OF PENTYLENETETRAZOLE IN MICE,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 3, no. 2, pp. 49–54, 2015, [Online]. Available: https://sid.ir/paper/258028/en

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