THE EFFECT OF BIO, A SPECIFIC GSK3-Β INHIBITOR, ON THE EXPRESSION OF NEUROPROTECTIVE FACTOR TGFβ IN CULTURED ASTROCYTES

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PARVANEH TAFRESHI A.; PIROOZI A.; KASHANI F.; DARVISH ALIPOUR ASTANEH S.; ZEYNALI B.

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Journal: IRANIAN JOURNAL OF BIOLOGY Year:2012 | Volume:25 | Issue:1 Page(s): 111-119

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Title

THE EFFECT OF BIO, A SPECIFIC GSK3-Β INHIBITOR, ON THE EXPRESSION OF NEUROPROTECTIVE FACTOR TGFβ IN CULTURED ASTROCYTES

Author(s)

Keywords

GSK3βQ2

BIOQ2

ASTROCYTEQ2

TGFβQ2

Abstract

Astrocytes are the most important glial cells of the central nervous system, ten times as much as neurons and with the ability of neuroprotection against injuries, ischemia, etc.Apoptosis of the ASTROCYTEs therefore leads to disease progression in neurodegenerative patients such as Alzheimer's and Parkinson's diseases. Investigations on possible signaling pathway (s) involved in neuron death suggest that GSK3-b "glycogen synthase kinase-3b", a key molecule of the Wnt and PI-3 kinase signaling pathways, is considerably increased in neurodegenerative diseases. In this study we sought to determine if the expression of neuroprotective factors such as TGFb1 and TGFb2 in cultured ASTROCYTEs is altered by inhibition of GSK3-b. Different concentrations of BIO, a specific inhibitor of GSK3-b (0.1 mM, 0.5 mM and 1 mM) were therefore used. The treated and control ASTROCYTEs were isolated after 48 hours and monitored for the expression of TGFb1mRNA and TGFb2mRNA using real-time RT-PCR. Our results show that the BIO treated cells express much higher amounts of TGFb1 and TGFb2 in comparison with the control cells. The increased expression of TGFbs following the inhibition of GSK3-b points at the involvement of GSK3-b in neuroprotective activity of ASTROCYTEs.

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APA: Copy

PARVANEH TAFRESHI, A., PIROOZI, A., KASHANI, F., DARVISH ALIPOUR ASTANEH, S., & ZEYNALI, B.. (2012). THE EFFECT OF BIO, A SPECIFIC GSK3-Β INHIBITOR, ON THE EXPRESSION OF NEUROPROTECTIVE FACTOR TGFβ IN CULTURED ASTROCYTES. IRANIAN JOURNAL OF BIOLOGY, 25(1), 111-119. SID. https://sid.ir/paper/21538/en

Vancouver: Copy

PARVANEH TAFRESHI A., PIROOZI A., KASHANI F., DARVISH ALIPOUR ASTANEH S., ZEYNALI B.. THE EFFECT OF BIO, A SPECIFIC GSK3-Β INHIBITOR, ON THE EXPRESSION OF NEUROPROTECTIVE FACTOR TGFβ IN CULTURED ASTROCYTES. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2012;25(1):111-119. Available from: https://sid.ir/paper/21538/en

IEEE: Copy

A. PARVANEH TAFRESHI, A. PIROOZI, F. KASHANI, S. DARVISH ALIPOUR ASTANEH, and B. ZEYNALI, “THE EFFECT OF BIO, A SPECIFIC GSK3-Β INHIBITOR, ON THE EXPRESSION OF NEUROPROTECTIVE FACTOR TGFβ IN CULTURED ASTROCYTES,” IRANIAN JOURNAL OF BIOLOGY, vol. 25, no. 1, pp. 111–119, 2012, [Online]. Available: https://sid.ir/paper/21538/en

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