EFFECTS OF MODERATE INTENSITY TRAINING ON MALONDIALDEHYDE AND BRAIN DERIVED NEUROTROPHIC FACTOR IN HIPPOCAMPUS OF RATS EXPOSED TO LEAD ACETATE

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DABIDI ROSHAN V.; HOSSEINZADEH S.; HAJIZADEH MOGHADAM A.; MAHJOUB S.

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Journal: SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE) Year:2011 | Volume:3 | Issue:10 Page(s): 33-44

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Title

EFFECTS OF MODERATE INTENSITY TRAINING ON MALONDIALDEHYDE AND BRAIN DERIVED NEUROTROPHIC FACTOR IN HIPPOCAMPUS OF RATS EXPOSED TO LEAD ACETATE

Author(s)

DABIDI ROSHAN V. | HOSSEINZADEH S. | HAJIZADEH MOGHADAM A. | MAHJOUB S. | Issue Writer Certificate

Keywords

OXIDATIVE STRESSQ2

MODERATE TRAININGQ2

BDNFQ2

HIPPOCAMPUSQ1

LEAD ACETATEQ2

Abstract

Available studies show that the moderate intensity training which reduces the parameters of OXIDATIVE STRESS in the HIPPOCAMPUS, resulting increasing the brain-derived neurotrophic factor (BDNF) levels. However, less attention has been paid to examine exercise-induced neuroprotection after administration of LEAD ACETATE. In this research, the effects of 8-weeks of exercise training on malondialdehyde (MDA) and BDNF levels in HIPPOCAMPUS of rats exposed to LEAD ACETATE were investigated. The Wistar rats were randomly assigned into following four groups: Base, Sham (control), LEAD ACETATE (L), and training+lead acetate (Ex-L) groups. The exercise training protocol consisted of running on treadmill at a progressive intensity for 8 weeks and five sessions a week. Ex-L and L groups received 20 mg/kg LEAD ACETATE, peritoneally, for 8 weeks (3 days in weeks). Twenty four hours after the last session of training and/or injection, MDA and BDNF levels were measured by TBARS and ELISA methods in rat HIPPOCAMPUS region, respectively. Data were analyzed by using one-way ANOVA and Tukey at P<0.05. Results showed that MDA concentrations in the Ex-L group were significantly lower and in L group were significantly higher than Sham and Base groups. BDNF levels in the Ex-L group were significantly higher than Lead group. These results indicate the beneficial effects of regular exercise training in preventing damage to hippocampal neurons, which contributes to OXIDATIVE STRESS. Furthermore, probably BDNF levels and oxidative status may be involved in the mechanisms of exercise-induced neuroprotection after administration of LEAD ACETATE.

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APA: Copy

DABIDI ROSHAN, V., HOSSEINZADEH, S., HAJIZADEH MOGHADAM, A., & MAHJOUB, S.. (2011). EFFECTS OF MODERATE INTENSITY TRAINING ON MALONDIALDEHYDE AND BRAIN DERIVED NEUROTROPHIC FACTOR IN HIPPOCAMPUS OF RATS EXPOSED TO LEAD ACETATE. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), 3(10), 33-44. SID. https://sid.ir/paper/228323/en

Vancouver: Copy

DABIDI ROSHAN V., HOSSEINZADEH S., HAJIZADEH MOGHADAM A., MAHJOUB S.. EFFECTS OF MODERATE INTENSITY TRAINING ON MALONDIALDEHYDE AND BRAIN DERIVED NEUROTROPHIC FACTOR IN HIPPOCAMPUS OF RATS EXPOSED TO LEAD ACETATE. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE)[Internet]. 2011;3(10):33-44. Available from: https://sid.ir/paper/228323/en

IEEE: Copy

V. DABIDI ROSHAN, S. HOSSEINZADEH, A. HAJIZADEH MOGHADAM, and S. MAHJOUB, “EFFECTS OF MODERATE INTENSITY TRAINING ON MALONDIALDEHYDE AND BRAIN DERIVED NEUROTROPHIC FACTOR IN HIPPOCAMPUS OF RATS EXPOSED TO LEAD ACETATE,” SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), vol. 3, no. 10, pp. 33–44, 2011, [Online]. Available: https://sid.ir/paper/228323/en

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