Designing and Evaluation of the Structure and Functions of New Immunotoxins for Ovarian Cancer in Quasi-Physiological Conditions

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Sabagh R.; HADDAD MASHADRIZEH A.A.; DOLATABADI S.

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Journal: JOURNAL OF BIOTECHNOLOGY Year:2019 | Volume:10 | Issue:2 Page(s): 201-209

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Title

Designing and Evaluation of the Structure and Functions of New Immunotoxins for Ovarian Cancer in Quasi-Physiological Conditions

Author(s)

Sabagh R. | HADDAD MASHADRIZEH A.A. | DOLATABADI S. | Issue Writer Certificate

Keywords

ImmunotoxinQ1

ToxinQ1

LigandsQ1

AntigenQ1

MAGE4Q1

Abstract

Toxin/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">ImmunoToxins, as a critical approach for cancer therapy, have ability to induction death in cancerous cells based on specific Ligands for targeting cancer-specific Antigens and Toxin domains in its context. Bearing in mind, discovery the cancer-specific Antigens, as well as Toxin/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">ImmunoToxin characterization for modeling based on linkers application, is a critical step for drugs design, which is considered in this study for ovarian cancer based on in-silico biology. The results of this study, led to the detection of 29 Antigens with expression capacity on the surface of ovarian cancer cells, with the highest and specific expression associated with MAGE4 and CA125 Antigens. Moreover, the 3D structure of MAGE4 was performed, and the pattern of its expression was determined to rely on HLA proteins. On the other hand, among connecting proteins to this Antigen TRIM69 selected as the most effective ligand. Subsequently, the assembling between the domain of Corynebacterium diphtheria and this ligand with (GGGGS) 3 linker in 5 positions led to the creation of 50 models, with different quality and structure. However, among these models, S4 drug showed the best structure and function including binding affinity and immunogenicity after simulation in physiological condition. Generally, this result led to present the MAGE4 as a suitable candidate for Toxin/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">ImmunoToxin development for ovarian cancer, as well as an effective Toxin/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">ImmunoToxin which should be considered in an experimental condition.

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APA: Copy

Sabagh, R., HADDAD MASHADRIZEH, A.A., & DOLATABADI, S.. (2019). Designing and Evaluation of the Structure and Functions of New Immunotoxins for Ovarian Cancer in Quasi-Physiological Conditions. JOURNAL OF BIOTECHNOLOGY, 10(2 ), 201-209. SID. https://sid.ir/paper/231221/en

Vancouver: Copy

Sabagh R., HADDAD MASHADRIZEH A.A., DOLATABADI S.. Designing and Evaluation of the Structure and Functions of New Immunotoxins for Ovarian Cancer in Quasi-Physiological Conditions. JOURNAL OF BIOTECHNOLOGY[Internet]. 2019;10(2 ):201-209. Available from: https://sid.ir/paper/231221/en

IEEE: Copy

R. Sabagh, A.A. HADDAD MASHADRIZEH, and S. DOLATABADI, “Designing and Evaluation of the Structure and Functions of New Immunotoxins for Ovarian Cancer in Quasi-Physiological Conditions,” JOURNAL OF BIOTECHNOLOGY, vol. 10, no. 2 , pp. 201–209, 2019, [Online]. Available: https://sid.ir/paper/231221/en

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