The effects of Nanocurcumin on Expression Induction of Transcription Factors Involved in Hematopoietic Stem Cell Differentiation to Precursor Myeloid Cells

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Mortazavi Farsani S.S.; SADEGHIZADEH M.; SHIRZAD H.; NAJAFI F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF BIOTECHNOLOGY Year:2019 | Volume:10 | Issue:4 Page(s): 601-608

Download Full-Text

Persian Verion

View:

319

Download:

Cites:

Information Journal Paper

Title

The effects of Nanocurcumin on Expression Induction of Transcription Factors Involved in Hematopoietic Stem Cell Differentiation to Precursor Myeloid Cells

Author(s)

Mortazavi Farsani S.S. | SADEGHIZADEH M. | SHIRZAD H. | NAJAFI F. | Issue Writer Certificate

Keywords

Hematopoietic stem cellsQ1

Myeloid DifferentiationQ1

NanocurcuminQ1

Abstract

Aims Hematopoietic stem cells are responsible for the production of blood cells in the bone marrow. During the process of differentiation, these cells commitment to two precursor cell lines include myeloid and lymphoid cells. Various blood cells, excluded lymphocytes, generates from myeloid cells. Some patients with severe anemia or thrombocytopenia receive hematopoietic stem cell through transplantation. Finding a potential component for inducing differentiation of Hematopoietic stem cells before transplantation, could be an appropriate strategy for the acceleration of blood cells production in recipient persons. Various studies indicate the ability of Curcumin for inducing of cell differentiation. This component can alter many of cellular mechanisms. Material and methods The aim of this project was to evaluate the effects of Nanocurcumin on mRNA expression levels of GATA1, GATA2, c-Myb and Hhex genes and alteration of cellular ROS in umbilical cord blood-derived Hematopoietic stem cells. Nanocurcumin was synthesized from Curcumin, Oleic acid, and PEG400. The rate of Nanocurcumin delivery into the cells was also evaluated. Findings Our results show that intracellular ROS and expression levels of GATA1, c-Myb, and Hhex transcription factors were significantly increased after treatment with Nanocurcumin (p<0. 05). These transcription factors involve in Myeloid Differentiation. Conclusion Enhancement of these transcription factors expression making Nanocurcumin a potential candidate for applying in Myeloid Differentiation media and basic and clinical studies.

Cites

No record.

References

No record.

Cite

APA: Copy

Mortazavi Farsani, S.S., SADEGHIZADEH, M., SHIRZAD, H., & NAJAFI, F.. (2019). The effects of Nanocurcumin on Expression Induction of Transcription Factors Involved in Hematopoietic Stem Cell Differentiation to Precursor Myeloid Cells. JOURNAL OF BIOTECHNOLOGY, 10(4 ), 601-608. SID. https://sid.ir/paper/231252/en

Vancouver: Copy

Mortazavi Farsani S.S., SADEGHIZADEH M., SHIRZAD H., NAJAFI F.. The effects of Nanocurcumin on Expression Induction of Transcription Factors Involved in Hematopoietic Stem Cell Differentiation to Precursor Myeloid Cells. JOURNAL OF BIOTECHNOLOGY[Internet]. 2019;10(4 ):601-608. Available from: https://sid.ir/paper/231252/en

IEEE: Copy

S.S. Mortazavi Farsani, M. SADEGHIZADEH, H. SHIRZAD, and F. NAJAFI, “The effects of Nanocurcumin on Expression Induction of Transcription Factors Involved in Hematopoietic Stem Cell Differentiation to Precursor Myeloid Cells,” JOURNAL OF BIOTECHNOLOGY, vol. 10, no. 4 , pp. 601–608, 2019, [Online]. Available: https://sid.ir/paper/231252/en

Related Journal Papers