The effect of 12 weeks of submaximal swimming training on immunoreactivity of Ras and Raf-1 in lung epithelial cells of Wistar rats exposed to carcinogen NNK

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MIRDAR HARIJANI SH.; Musavi N.

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Journal: Research in Sport Medicine and Technology Year:2020 | Volume:9 | Issue:19 Page(s): 113-126

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Title

The effect of 12 weeks of submaximal swimming training on immunoreactivity of Ras and Raf-1 in lung epithelial cells of Wistar rats exposed to carcinogen NNK

Author(s)

MIRDAR HARIJANI SH. | Musavi N. | Issue Writer Certificate

Keywords

LungQ1

CancerQ1

Cigarette SmokeQ1

nAChRsQ1

β-ARsQ1

Abstract

The aim of this study was to investigate changes in immunoreactivity of Ras and Raf-1 in Lung epithelial cells of rats exposed to carcinogen NNK after swimming training. 50 Wistar rats were randomly divided into five groups: control, training, training + NNK, NNK and sham. NNK-induced groups received NNK Subcutaneously once a week at a dose of 12/5 mg per kg body weight for 12 weeks. The exercise training consisted of submaximal swimming training for 12 weeks. The percentage of reaction of Ras and Raf-1 in Lung epithelial cells were measured by HIC. It was observed no significant change in the Ras and Raf-1 immunoreactivity of Lung epithelial cells in training group compared to control. A significant incretion of the Ras and Raf-1 immunoreactivity was found in NNK group compared to control group (p=0. 001). Furthermore, a significant reduction of the Ras and Raf-1 immunoreactivity was observed in exercise + NNK group when compared to NNK group (p=0. 001). Generally it could be confirmed that regular submaximal aerobic training plays an important role in inhibition of the effects of Lung carcinoma induced by NNK via reduction of Ras and Raf-1 activity.

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APA: Copy

MIRDAR HARIJANI, SH., & Musavi, N.. (2020). The effect of 12 weeks of submaximal swimming training on immunoreactivity of Ras and Raf-1 in lung epithelial cells of Wistar rats exposed to carcinogen NNK. RESEARCH IN SPORT MEDICINE & TECHNOLOGY, 9(19 ), 113-126. SID. https://sid.ir/paper/231424/en

Vancouver: Copy

MIRDAR HARIJANI SH., Musavi N.. The effect of 12 weeks of submaximal swimming training on immunoreactivity of Ras and Raf-1 in lung epithelial cells of Wistar rats exposed to carcinogen NNK. RESEARCH IN SPORT MEDICINE & TECHNOLOGY[Internet]. 2020;9(19 ):113-126. Available from: https://sid.ir/paper/231424/en

IEEE: Copy

SH. MIRDAR HARIJANI, and N. Musavi, “The effect of 12 weeks of submaximal swimming training on immunoreactivity of Ras and Raf-1 in lung epithelial cells of Wistar rats exposed to carcinogen NNK,” RESEARCH IN SPORT MEDICINE & TECHNOLOGY, vol. 9, no. 19 , pp. 113–126, 2020, [Online]. Available: https://sid.ir/paper/231424/en

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