DETERMINATION HCV GENOTYPE IN HIGH RISK GROUP (HEMOPHILIA-TALASEMIC-DIALYSIS-IV DRUG USER) IN MAZANDARAN PROVINCE IN SARI CITY

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RAFIEI A.R.; HOSSEINIKHAH Z.; HAGHSHENAS M.R.; TAHERI S.; DARZIANI M.

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Journal: Biotechnological Journal of Environmental Microorganisms Year:2012 | Volume: | Issue: Page(s): 21-31

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Title

DETERMINATION HCV GENOTYPE IN HIGH RISK GROUP (HEMOPHILIA-TALASEMIC-DIALYSIS-IV DRUG USER) IN MAZANDARAN PROVINCE IN SARI CITY

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Keywords

HCV GENOTYPEQ2

PREVALENCEQ2

TRANSFUSION BLOODQ2

EPIDEMICQ2

Abstract

Hepatitis C virus (HCV) is the major infectious disease agent among intravenous drug addicts, Thalassemiac, Hemophiliac, hemodialysis patients, who were nominated as population at high risk of acquiring hepatitis C infection. Hepatitis C virus is spread either through intravenous drug use or, in lesser-developed countries, through the frequently blood transfusions or blood contamination during medical procedures. Genotype determination of HCV is clinically valuable as it provides important information which can be used to determine the type and duration of therapy and to predict the outcome. We carried out this study to provide epidemiologic data on hepatitis C virus genotype among this high-risk population in mazandaran province, Iran. This cross-sectional study was conducted on 132 patients with established hepatitis C infection. All samples were submitted to RNA extraction, We used manual protocol to RNA extraction upon RNX- plus solution (Cinnagen) reverse transcription and PCR genotyping. By Amplysens HCV-genotype kit. Genotypes were determined. Genotyping analysis determined that Type 3a was the most frequent type, (%71.2), followed by type 1b ….%8.3 and 1a ( %8.3), mixed HCV GENOTYPEs were found in 6 (1a/1b …%8.3), 2 (2/3a...%2.3 ), /1b/1c (%1.5) we had no genotype 2 in this populate. Our results are in accordance with other reports that genotypes 3a, 1a are dominant in Iran which is different from Europe, USA and even some parts of Asia. It is important to note that Genotype3 has high PREVALENCE in Iran, and represent more response to treatment and in comprise with Genotype 1 and Genotype 4 has high rate of slow virological response (SVR).But rate of recur in patients who have infected by Genotype 3 is more than those who have infected by Genotype2.Reasons of high PREVALENCE of Genotype3 in Iran maybe are due to geographical situations or ethics backgrounds. Frequency of Genotype3 in Iran is same as different parts of India and some regions of west southern of Asia. This analogues maybe due to geographical adjacency and long-term history of travelling, trade and connections between people of these regions.

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APA: Copy

RAFIEI, A.R., HOSSEINIKHAH, Z., HAGHSHENAS, M.R., TAHERI, S., & DARZIANI, M.. (2012). DETERMINATION HCV GENOTYPE IN HIGH RISK GROUP (HEMOPHILIA-TALASEMIC-DIALYSIS-IV DRUG USER) IN MAZANDARAN PROVINCE IN SARI CITY. BIOTECHNOLOGICAL JOURNAL OF ENVIRONMENTAL MICROORGANISMS, 6(1), 21-31. SID. https://sid.ir/paper/242208/en

Vancouver: Copy

RAFIEI A.R., HOSSEINIKHAH Z., HAGHSHENAS M.R., TAHERI S., DARZIANI M.. DETERMINATION HCV GENOTYPE IN HIGH RISK GROUP (HEMOPHILIA-TALASEMIC-DIALYSIS-IV DRUG USER) IN MAZANDARAN PROVINCE IN SARI CITY. BIOTECHNOLOGICAL JOURNAL OF ENVIRONMENTAL MICROORGANISMS[Internet]. 2012;6(1):21-31. Available from: https://sid.ir/paper/242208/en

IEEE: Copy

A.R. RAFIEI, Z. HOSSEINIKHAH, M.R. HAGHSHENAS, S. TAHERI, and M. DARZIANI, “DETERMINATION HCV GENOTYPE IN HIGH RISK GROUP (HEMOPHILIA-TALASEMIC-DIALYSIS-IV DRUG USER) IN MAZANDARAN PROVINCE IN SARI CITY,” BIOTECHNOLOGICAL JOURNAL OF ENVIRONMENTAL MICROORGANISMS, vol. 6, no. 1, pp. 21–31, 2012, [Online]. Available: https://sid.ir/paper/242208/en

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