ASSOCIATION STUDY OF MBL2 EXON 1 POLYMORPHISMS AND ITS RELATION TO SERUM MBL LEVEL IN TEHRAN POPULATION

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SOLTANI A.; RAHMATI RAD S.; POURPAK Z.; ALIZADEH Z.; HAJI BEIGI B.; ZEIDI M.; FARAZMAND A.

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Journal: Journal of Molecular and Cellular Researches Year:2014 | Volume:26 | Issue:4 Page(s): 491-498

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Title

ASSOCIATION STUDY OF MBL2 EXON 1 POLYMORPHISMS AND ITS RELATION TO SERUM MBL LEVEL IN TEHRAN POPULATION

Author(s)

Keywords

MANNOSE-BINDING LECTINQ2

MBL2Q2

POLYMORPHISMQ2

Abstract

Mannose Binding Lectin (MBL) is a major initiator of the lectin pathway (LP) of complement System. MBL produced by the liver and involved in the innate immunity response. We have analyzed three SNPs of MBL2 gene at the exon 1 individuals of a random population residing in Tehran (N=143), and have correlated genotypes with respective MBL serum concentration. POLYMORPHISMs in exon 1 of the MBL are reported to be associated with impaired MBL function and in response of the body to infection. Three different mutations within exon 1 of the MBL gene have been described, each causing MBL deficiency. Three SNPs in exon 1 were genotyped using PCR amplification. Plasma level of MBL were quantified using ELISA. Our research showed 3 variant POLYMORPHISMs at codon 52 (D Allele), 54 (B Allele), 57 (C Allele) of MBL2 gene affecting the protein level in plasma. B allele was significantly correlated with the lowest MBL level.

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APA: Copy

SOLTANI, A., RAHMATI RAD, S., POURPAK, Z., ALIZADEH, Z., HAJI BEIGI, B., ZEIDI, M., & FARAZMAND, A.. (2014). ASSOCIATION STUDY OF MBL2 EXON 1 POLYMORPHISMS AND ITS RELATION TO SERUM MBL LEVEL IN TEHRAN POPULATION. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 26(4), 491-498. SID. https://sid.ir/paper/248404/en

Vancouver: Copy

SOLTANI A., RAHMATI RAD S., POURPAK Z., ALIZADEH Z., HAJI BEIGI B., ZEIDI M., FARAZMAND A.. ASSOCIATION STUDY OF MBL2 EXON 1 POLYMORPHISMS AND ITS RELATION TO SERUM MBL LEVEL IN TEHRAN POPULATION. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2014;26(4):491-498. Available from: https://sid.ir/paper/248404/en

IEEE: Copy

A. SOLTANI, S. RAHMATI RAD, Z. POURPAK, Z. ALIZADEH, B. HAJI BEIGI, M. ZEIDI, and A. FARAZMAND, “ASSOCIATION STUDY OF MBL2 EXON 1 POLYMORPHISMS AND ITS RELATION TO SERUM MBL LEVEL IN TEHRAN POPULATION,” JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 26, no. 4, pp. 491–498, 2014, [Online]. Available: https://sid.ir/paper/248404/en

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