INDUCTION EFFECTS OF COLCHICINE AND CHITOSAN ON ROSMARINIC ACID PRODUCTION IN HAIRY ROOT CULTURES OF ZARRIN-GIAH (DRACOCEPHALUM KOTSCHYI BOISS

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AYYOBI N.; HOSSEINI B.; FATTAHI M.

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Journal: Journal of Molecular and Cellular Researches Year:2017 | Volume:30 | Issue:1 Page(s): 1-13

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Title

INDUCTION EFFECTS OF COLCHICINE AND CHITOSAN ON ROSMARINIC ACID PRODUCTION IN HAIRY ROOT CULTURES OF ZARRIN-GIAH (DRACOCEPHALUM KOTSCHYI BOISS

Author(s)

AYYOBI N. | HOSSEINI B. | FATTAHI M. | Issue Writer Certificate

Keywords

AGROBACTERIUM RHIZOGENESQ1

ROSMARINIC ACIDQ1

HAIRY ROOTSQ2

ELICITORSQ1

Abstract

Dracocephalum kotschyi Boiss belonging to Labiateae family is an herbaceous, pereninal and endemic plant known in Iran as Zarrin-Giah. Recent pharmacological studies demonstrated this plants with methoxylated flavonoids, have anti-cancer effects.Hairy roots were obtained from leaves explants, inoculated with 15834 strain of AGROBACTERIUM RHIZOGENESis. In present study, The effects of biotic ELICITORS including, Colchicine with different cocentrations (0, 0.01, 0.03 and 0.05% (w/v)) and Chitosan (0, 50, 100 and 150 mg/l) for 48 hours on hairy root growth and ROSMARINIC ACID production were investigated. ANOVA results of Antioxidant activity, total phenol and total flavonoids showed significant difference among the various treatments (P<0.01).maximum Antioxidant activity (90.23%) was observed in 0.05% colchicine and lowest Antioxidant activity (63%) was observed in non-transformed roots. HPLC analysis revealed that the maximum ROSMARINIC ACID content (35.8 and 15.1 mg /mg DW) obtained in colchicine (0.05%) and chitosan (100 mg/l) respectively. Although minimum ROSMARINIC ACID content (13.8 mg /mg DW) were recorded in no transformed roots. based on the importance of ROSMARINIC ACID production in the pharmaceutical industry, the results showed that using biotechnological methods, production improving of valuable medicinal substances is acceptable.

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APA: Copy

AYYOBI, N., HOSSEINI, B., & FATTAHI, M.. (2017). INDUCTION EFFECTS OF COLCHICINE AND CHITOSAN ON ROSMARINIC ACID PRODUCTION IN HAIRY ROOT CULTURES OF ZARRIN-GIAH (DRACOCEPHALUM KOTSCHYI BOISS. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 30(1 ), 1-13. SID. https://sid.ir/paper/248507/en

Vancouver: Copy

AYYOBI N., HOSSEINI B., FATTAHI M.. INDUCTION EFFECTS OF COLCHICINE AND CHITOSAN ON ROSMARINIC ACID PRODUCTION IN HAIRY ROOT CULTURES OF ZARRIN-GIAH (DRACOCEPHALUM KOTSCHYI BOISS. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2017;30(1 ):1-13. Available from: https://sid.ir/paper/248507/en

IEEE: Copy

N. AYYOBI, B. HOSSEINI, and M. FATTAHI, “INDUCTION EFFECTS OF COLCHICINE AND CHITOSAN ON ROSMARINIC ACID PRODUCTION IN HAIRY ROOT CULTURES OF ZARRIN-GIAH (DRACOCEPHALUM KOTSCHYI BOISS,” JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 30, no. 1 , pp. 1–13, 2017, [Online]. Available: https://sid.ir/paper/248507/en

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