Investigating the Mechanism of Selective Transport through the Pore Complex of the Cell Nucleus Using Molecular Dynamics Simulation

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Ghesmati Z.; Mohammadinejad S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Molecular and Cellular Researches Year:2018 | Volume:31 | Issue:2 Page(s): 279-291

Download Full-Text

Persian Verion

View:

1,831

Download:

Cites:

Information Journal Paper

Title

Investigating the Mechanism of Selective Transport through the Pore Complex of the Cell Nucleus Using Molecular Dynamics Simulation

Author(s)

Ghesmati Z. | Mohammadinejad S. | Issue Writer Certificate

Keywords

Nucleus pore complexQ1

coarse-grained molecular dynamics simulationQ1

selective transportQ1

brush-like structureQ1

Abstract

Nuclear pore complexes (NPCs) are selectively gated pathways between nucleoplasm and cytoplasm. Whereas small molecules can diffuse freely through NPCs, large molecules can pass only when bound to transport receptors. The NPC central channel is filled with disordered proteins, rich in phenylalanine-glycine (FG) repeats, called FGnups which are claimed to be responsible for selective function of NPCs. In this paper, the individual and collective behavior of Nsp1, as a representative of FG nups, has been studied using coarse-grained molecular dynamics simulations. In our coarse-grained model, detailed hydrophobic properties of amino acids are considered. Our simulation results show that individual FG-nups form globular structures, whereas arrays of FGnups tethered to a planar surface, form extended and brush-like structures. Moreover, NTF2 (Nuclear Transport Factor 2), as a transport receptor is observed to penetrate inside brush and also leads to its collapse. These observations indicate that virtual-gate model could be a suitable model for describing selective transport through NPCs.

Cites

No record.

References

No record.

Cite

APA: Copy

Ghesmati, Z., & Mohammadinejad, S.. (2018). Investigating the Mechanism of Selective Transport through the Pore Complex of the Cell Nucleus Using Molecular Dynamics Simulation. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 31(2 ), 279-291. SID. https://sid.ir/paper/248528/en

Vancouver: Copy

Ghesmati Z., Mohammadinejad S.. Investigating the Mechanism of Selective Transport through the Pore Complex of the Cell Nucleus Using Molecular Dynamics Simulation. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2018;31(2 ):279-291. Available from: https://sid.ir/paper/248528/en

IEEE: Copy

Z. Ghesmati, and S. Mohammadinejad, “Investigating the Mechanism of Selective Transport through the Pore Complex of the Cell Nucleus Using Molecular Dynamics Simulation,” JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 31, no. 2 , pp. 279–291, 2018, [Online]. Available: https://sid.ir/paper/248528/en

Related Journal Papers