GELATIN-CHITOSAN COATING ENHANCES L929 FIBROBLASTS PROLIFERATION ON SUPRAMOLECULAR NANO-FIBROUS SCAFFOLDS

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KHADEMI S.; SHOKROLLAHI P.; ZANDI M.; IRANI SH.

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Journal: Journal of Molecular and Cellular Researches Year:2015 | Volume:28 | Issue:4 Page(s): 500-512

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Title

GELATIN-CHITOSAN COATING ENHANCES L929 FIBROBLASTS PROLIFERATION ON SUPRAMOLECULAR NANO-FIBROUS SCAFFOLDS

Author(s)

KHADEMI S. | SHOKROLLAHI P. | ZANDI M. | IRANI SH. | Issue Writer Certificate

Keywords

SUPRAMOLECULAR POLYCAPROLACTONEQ2

TISSUE ENGINEERINGQ2

NANO-FIBERQ2

GELATIN/CHITOSAN BLENDQ2

SURFACE MODIFICATIONQ2

Abstract

The goal of TISSUE ENGINEERING is regeneration and restoration of damaged tissues and organs. Scaffolds are the main part of TISSUE ENGINEERING, and gelatin/chitosan SURFACE MODIFICATION is one of the proper methods for SURFACE MODIFICATION of polymer scaffolds. Evaluation of fibroblasts behavior on gelatin/chitosan coated supramolecular PCL (SP-PCL) was the aim of this study. SP-PCL NANO-FIBERs were prepared by electro spinning. Morphology of the nano-fibrous mats was investigated using scanning electron microscopy MTT assay was performed to examine cell activity on the nano fibers. DAPI staining was carried out to evaluate cell viability. The SEM images of the cells onto the scaffold showed good biocompatibility of the scaffold. In addition, the MTT assay results showed a proper metabolic activity of cells on the scaffolds The sPCL nano fibrous mats coated with gelatin-chitosan blend show significantly (p<0.05) increased cells proliferation compared to control (tissue culture plate, TCP), and also this significant increased proliferation has been observed until the seventh day post seeding. The experiments showed that the nano-fibrous electro spun SP-PCL coated with GELATIN/CHITOSAN BLEND, provides a suitable environment for fibroblasts adhesion, and proliferation, possibly because of similarity to nano-fibrous natural ECM network.

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APA: Copy

KHADEMI, S., SHOKROLLAHI, P., ZANDI, M., & IRANI, SH.. (2015). GELATIN-CHITOSAN COATING ENHANCES L929 FIBROBLASTS PROLIFERATION ON SUPRAMOLECULAR NANO-FIBROUS SCAFFOLDS. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 28(4), 500-512. SID. https://sid.ir/paper/248567/en

Vancouver: Copy

KHADEMI S., SHOKROLLAHI P., ZANDI M., IRANI SH.. GELATIN-CHITOSAN COATING ENHANCES L929 FIBROBLASTS PROLIFERATION ON SUPRAMOLECULAR NANO-FIBROUS SCAFFOLDS. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2015;28(4):500-512. Available from: https://sid.ir/paper/248567/en

IEEE: Copy

S. KHADEMI, P. SHOKROLLAHI, M. ZANDI, and SH. IRANI, “GELATIN-CHITOSAN COATING ENHANCES L929 FIBROBLASTS PROLIFERATION ON SUPRAMOLECULAR NANO-FIBROUS SCAFFOLDS,” JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 28, no. 4, pp. 500–512, 2015, [Online]. Available: https://sid.ir/paper/248567/en

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