NEW APPROACH TO THE IMMUNOMODULATORY EFFECTS OF CALCITRIOL IN NMRI-MOUSE

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ABTAHI FROUSHANI S.M.; ESMAEILI GOUVRCHIN GALEH H.; MANSORI MOTLAGH B.

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Paper Information

Journal: Journal of Molecular and Cellular Researches Year:2015 | Volume:28 | Issue:4 Page(s): 458-467

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Title

NEW APPROACH TO THE IMMUNOMODULATORY EFFECTS OF CALCITRIOL IN NMRI-MOUSE

Author(s)

ABTAHI FROUSHANI S.M. | ESMAEILI GOUVRCHIN GALEH H. | MANSORI MOTLAGH B. | Issue Writer Certificate

Keywords

CALCITRIOLQ2

HUMORAL IMMUNITYQ2

CELLULAR IMMUNITYQ2

LYMPHOCYTE RESPONSEQ2

Abstract

Recent evidence demonstrated an important role for Th-17 and FoxP3+Treg lymphocytes in immunity system. Although, previous reports have determined the immunomodulatory potential of CALCITRIOL, but this study was mostly done before the discovery of recent lymphocytes. The present study was set out to investigate the effects of CALCITRIOL on immunity system in NRMI-mice after challenge with sheep red blood cells (SRBC). The study population was consist of 14 male mice that randomly allocated in two equal groups and immunized with SRBC. Mice in the treatment group were intraperitoneally received 5mg/Kg CALCITRIOL every other day from the beginning of the study and continued for 2 weeks. The results of the present study indicated a significant increase in the level of anti-SRBC antibody and simultaneously a significant decrease in the level of DTH in the treatment group compared to control group. The level of respiratory burst in phagocytic cells of splenocytes and the level of lymphocyte proliferation were significantly decreased in treatment group compared to control group. Moreover, CALCITRIOL caused a significant reduction in the production of proinflammatory IL-17 as well as IFN-g, parallel to increasing FoxP3+Treg cells. Also the level of anti-inflammatory IL-10 was significantly increased. Therefore, the major immunomudlatoty effects of calciteriol may be due to a significant decrease in Th17 cells activity and concurrently a significant decrease in the expansion of FoxP3+Treg lymphocytes.

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APA: Copy

ABTAHI FROUSHANI, S.M., ESMAEILI GOUVRCHIN GALEH, H., & MANSORI MOTLAGH, B.. (2015). NEW APPROACH TO THE IMMUNOMODULATORY EFFECTS OF CALCITRIOL IN NMRI-MOUSE. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 28(4), 458-467. SID. https://sid.ir/paper/248579/en

Vancouver: Copy

ABTAHI FROUSHANI S.M., ESMAEILI GOUVRCHIN GALEH H., MANSORI MOTLAGH B.. NEW APPROACH TO THE IMMUNOMODULATORY EFFECTS OF CALCITRIOL IN NMRI-MOUSE. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2015;28(4):458-467. Available from: https://sid.ir/paper/248579/en

IEEE: Copy

S.M. ABTAHI FROUSHANI, H. ESMAEILI GOUVRCHIN GALEH, and B. MANSORI MOTLAGH, “NEW APPROACH TO THE IMMUNOMODULATORY EFFECTS OF CALCITRIOL IN NMRI-MOUSE,” JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 28, no. 4, pp. 458–467, 2015, [Online]. Available: https://sid.ir/paper/248579/en

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