EFFECTS OF TREATMENT WITH ORAL CALCITRIOL ON PLASMA GLUCOSE AND INSULIN LEVELS IN NON-INSULIN DEPENDENT DIABETES MELLITUS PATIENTS

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EFTEKHARI M.H.; AKBARZADEH M.; DABBAGHMANESH M.H.; HASANZADEH J.

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Journal: Iranian Journal of Nutrition Sciences and Food Technology Year:2011 | Volume:6 | Issue:3 (22) Page(s): 1-10

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Title

EFFECTS OF TREATMENT WITH ORAL CALCITRIOL ON PLASMA GLUCOSE AND INSULIN LEVELS IN NON-INSULIN DEPENDENT DIABETES MELLITUS PATIENTS

Author(s)

EFTEKHARI M.H. | AKBARZADEH M. | DABBAGHMANESH M.H. | HASANZADEH J. | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ2

CALCITRIOLQ3

FASTING GLUCOSEQ3

INSULIN RESISTANCEQ2

Abstract

Background and Objective: Type-2 diabetes is a major metabolic disease with many signs and symptoms, such as hyperglycemia, disorders in protein, carbohydrate and lipid metabolism, and partial or total insulin deficiency. It is accompanied with pancreatic beta-cell malfunction, reduced insulin sensitivity, and systemic inflammation. There is some evidence indicating a role of vitamin D in maintaining glucose tolerance and normal secretion of insulin. The objective of the present study was to assess the effects of CALCITRIOL on the plasma insulin and glucose levels in non-insulin dependent DIABETES MELLITUS patients.Materials and Methods: Seventy subjects (35 males and 35 female) with type-2 diabetes, aged 30-75 years old, were divided into 2 groups-an intervention and a control group. The intervention and control groups received, daily for 12 weeks, two 0.25-mcg calcitrio-capsules (0.5 mcg CALCITRIOL) and 2 placebo capsules, respectively. Fasting blood samples were taken at the beginning and at weeks 6 and 12 for measuring glucose, insulin, and glycosylated hemoglobin (HbA1C).Results: The fasting plasma glucose level did not change noticeably at weeks 0, 6 or 12 in the intervention group, while it increased significantly (p=0.03) in the control group. The insulin level increased significantly in both the experimental (p=0.002) and control (p=0.0002) groups. Similarly, there were increases in the HbA1C concentration in the experimental (p=0.013) and control (p=0.0004) groups at week 12, as compared to baseline values. Also there was an increase in INSULIN RESISTANCE in both groups (p=0.023 and 0.0001 for experimental and control groups, respectively). Finally, HOMA-%b, which is an indicator of the activity of the pancreatic beta-cells, remained unchanged in the controls, while it increased significantly in the experimental group (p=0.009).Conclusion: CALCITRIOL at a daily dose of 0.5 mcg has no lowering effect on blood glucose in type-2 diabetic patients, although it may prevent its elevation. The findings further show that CALCITRIOL dose not bring about a reduction in INSULIN RESISTANCE, however, it improves pancreatic beta-cell functioning, thereby increasing insulin secretion.

Cites

A double blind randomized clinical trial to investigate the effect of vitamin D supplementation on metabolic and hepato-renal markers in type 2 diabetes and obesity

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APA: Copy

EFTEKHARI, M.H., AKBARZADEH, M., DABBAGHMANESH, M.H., & HASANZADEH, J.. (2011). EFFECTS OF TREATMENT WITH ORAL CALCITRIOL ON PLASMA GLUCOSE AND INSULIN LEVELS IN NON-INSULIN DEPENDENT DIABETES MELLITUS PATIENTS. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, 6(3 (22)), 1-10. SID. https://sid.ir/paper/121500/en

Vancouver: Copy

EFTEKHARI M.H., AKBARZADEH M., DABBAGHMANESH M.H., HASANZADEH J.. EFFECTS OF TREATMENT WITH ORAL CALCITRIOL ON PLASMA GLUCOSE AND INSULIN LEVELS IN NON-INSULIN DEPENDENT DIABETES MELLITUS PATIENTS. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY[Internet]. 2011;6(3 (22)):1-10. Available from: https://sid.ir/paper/121500/en

IEEE: Copy

M.H. EFTEKHARI, M. AKBARZADEH, M.H. DABBAGHMANESH, and J. HASANZADEH, “EFFECTS OF TREATMENT WITH ORAL CALCITRIOL ON PLASMA GLUCOSE AND INSULIN LEVELS IN NON-INSULIN DEPENDENT DIABETES MELLITUS PATIENTS,” JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, vol. 6, no. 3 (22), pp. 1–10, 2011, [Online]. Available: https://sid.ir/paper/121500/en

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