SEQUENCE ANALYSES, ANTIGENIC CHARACTERISTIC AND THREE-DIMENSIONAL STRUCTURE OF RICE NONSPECIFIC LIPID TRANSFER PROTEIN 2: A BIOINFORMATICS STUDY

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DARVISHI F.Z.; MIROLIAEI M.; EMAMZADEH R.; MOTAVALI BASHI M.; NAZARI M.

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Journal: Journal of Molecular and Cellular Researches Year:2015 | Volume:28 | Issue:2 Page(s): 211-222

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Title

SEQUENCE ANALYSES, ANTIGENIC CHARACTERISTIC AND THREE-DIMENSIONAL STRUCTURE OF RICE NONSPECIFIC LIPID TRANSFER PROTEIN 2: A BIOINFORMATICS STUDY

Author(s)

Keywords

NSLTP2Q2

HOMOLOGY MODELINGQ2

DRUG DELIVERYQ1

ANTIMICROBIAL ACTIVITYQ2

Abstract

Nonspecific lipid transfer protein 2 (NSLTP2) is among prolamin super family, capable of transferring various lipophilic molecules such as sterols. Despite advantages of the protein in DRUG DELIVERY systems, there are some reports on its allergenic properties. Comparative sequence analysis displayed at least 51% homology in different species of rice-NSLTP2. The aim of the current study was to evaluate gene sequence and protein structure analysis of Iranian rice-NSLTP2, by means of bioinformatics tools, to improve its potential capability for DRUG DELIVERY systems. Gene sequence homology assessment revealed resemblance mostly with Japonica species (Accession NO. NP-0011048723.1). The presence of various specific sites and motifs in the structure of NSLTP2 were determined by sequence analysis. Preliminary studies demonstrated four antigenic determinants in the primary sequence of the protein, which three of them retain after post translational modification. Moreover, sequence assessment revealed that those residues contributing in the protein cavity are conserved totally among Japonica and Iranian species. Modeling approaches were used to determine the influence of deletion of allergenic sites on protein affinity toward hydrophobic ligands. The obtained results revealed the efficacy of NSLTP2, as a drug carrier protein, could be improve by appropriate swap at specific residues and elision of allergenic sites.

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APA: Copy

DARVISHI, F.Z., MIROLIAEI, M., EMAMZADEH, R., MOTAVALI BASHI, M., & NAZARI, M.. (2015). SEQUENCE ANALYSES, ANTIGENIC CHARACTERISTIC AND THREE-DIMENSIONAL STRUCTURE OF RICE NONSPECIFIC LIPID TRANSFER PROTEIN 2: A BIOINFORMATICS STUDY. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 28(2), 211-222. SID. https://sid.ir/paper/248614/en

Vancouver: Copy

DARVISHI F.Z., MIROLIAEI M., EMAMZADEH R., MOTAVALI BASHI M., NAZARI M.. SEQUENCE ANALYSES, ANTIGENIC CHARACTERISTIC AND THREE-DIMENSIONAL STRUCTURE OF RICE NONSPECIFIC LIPID TRANSFER PROTEIN 2: A BIOINFORMATICS STUDY. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2015;28(2):211-222. Available from: https://sid.ir/paper/248614/en

IEEE: Copy

F.Z. DARVISHI, M. MIROLIAEI, R. EMAMZADEH, M. MOTAVALI BASHI, and M. NAZARI, “SEQUENCE ANALYSES, ANTIGENIC CHARACTERISTIC AND THREE-DIMENSIONAL STRUCTURE OF RICE NONSPECIFIC LIPID TRANSFER PROTEIN 2: A BIOINFORMATICS STUDY,” JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 28, no. 2, pp. 211–222, 2015, [Online]. Available: https://sid.ir/paper/248614/en

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