Effect of Marshmallow Hydro alcoholic extract on improving passive avoidance memory disorders in male Wistar rats

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Eslimi Esfahani D.; ORYAN SH.; HATAMI M.

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Journal: Journal of Animal Research Year:2018 | Volume:31 | Issue:1 Page(s): 1-15

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Title

Effect of Marshmallow Hydro alcoholic extract on improving passive avoidance memory disorders in male Wistar rats

Author(s)

Eslimi Esfahani D. | ORYAN SH. | HATAMI M. | Issue Writer Certificate

Keywords

Beta-amyloidQ1

the passive avoidance memoryQ1

shuttle boxQ2

histological studiesQ1

Nissl bodiesQ1

Abstract

Background and aim: Alzheimer's disease begins in the Middle Ages, it progresses rapidly and leads to loss of individual mental health. Considering that the neuroprotective effect of Marshmallow (Althea officinalis)has been reported, in this study, the effect of the plant on Alzheimer's rat model and its effect on the improvement of passive avoidance memory was investigated. Methods: Alzheimer's was initially induced by intra-ventricular injection of Beta-amyloid peptide. In this experiment, male wistar rats (220-180 g) were used. The control group (no injection), sham group (saline injection), experimental group (injection of Beta-amyloid (40-1)) and the groups which received marshmallow extract in 10, 50, 100 and 250 milligrams per kilogram of body weight by intraperitoneal injection for 7 days before and three weeks after Beta-amyloid injection. shuttle box was used to study the learning and memory behavior and H & E and Nissl staining were conducted for histological studies. The obtained data were analyzed by SPSS software (ANOVA and Tukey tests). Results: Data showed that treatment with Beta-amyloid group at a dose of 100 mg/kg marshmallow extract increased behavioral indices in passive avoidance memory test, compared to sham group(P<0. 001) and reduced the amount of tissue damage and increasesd the number of Nissl bodies in the CA1 hippocampus area. Discussion: In this study, likely reducing the complications, caused by the antioxidant properties and the effect of the inhibitory acetylcholinesterase enzyme of the compounds of this plant, such as quercetin, camphorol, tannin, lecithin, pectin, sterol and coumarin, are related.

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APA: Copy

Eslimi Esfahani, D., ORYAN, SH., & HATAMI, M.. (2018). Effect of Marshmallow Hydro alcoholic extract on improving passive avoidance memory disorders in male Wistar rats. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 31(1 ), 1-15. SID. https://sid.ir/paper/248718/en

Vancouver: Copy

Eslimi Esfahani D., ORYAN SH., HATAMI M.. Effect of Marshmallow Hydro alcoholic extract on improving passive avoidance memory disorders in male Wistar rats. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2018;31(1 ):1-15. Available from: https://sid.ir/paper/248718/en

IEEE: Copy

D. Eslimi Esfahani, SH. ORYAN, and M. HATAMI, “Effect of Marshmallow Hydro alcoholic extract on improving passive avoidance memory disorders in male Wistar rats,” JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 31, no. 1 , pp. 1–15, 2018, [Online]. Available: https://sid.ir/paper/248718/en

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