Considering the effect of Golpar (Heracleum Persicum) essential oils on the acute hepatotoxcity induced by acetaminophen in Wistar rats

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DADKHAH A.; Khalaj gh.; FATEMI F.; DINI S.; Naeege s.; Fadaee Monfared m.

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Journal: Journal of Animal Research Year:2016 | Volume:29 | Issue:3 Page(s): 292-306

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Title

Considering the effect of Golpar (Heracleum Persicum) essential oils on the acute hepatotoxcity induced by acetaminophen in Wistar rats

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Keywords

AcetaminophenQ2

Stress oxidativeQ1

Golpar (Heracleum Persicum) essential oilQ1

Liver enzymesQ2

Abstract

In this study, the protective effect of Iranian Golpar on the acute hepatotoxicity due to Acetaminophen over doses has evaluated. 80 Wistar male rats were randomly divided in to 4 groups (n=5). Control groups, only DMSO and Acetaminophen groups, 500 mg/kg b. w. injection of Acetaminophen (i. p) dissolved in DMSO received. Treatment groups received Golpar essential oils (100 and 200 mg/kg b. w) with Acetaminophen (500 mg/kg b. w) (i. p). Then, the rats were killed after 4, 8, 16 and 24 h and their plasma and liver tissues were collected for estimating the concentration of glutathione (GSH), proxidasion lipids (MDA) and the total antioxidant capacity of plasma and the activity of glutathione s-transferase (GST) with biochemical methods were estimated. Indeed, the levels of Liver enzymes; alanin Teransferase (ALT), aspartate Teransferase (AST), and alkaline phosphatase ALP of the serum were measured. Hence, the histopathology assessments were performed in the liver. The results of the study showed that the Golpar essential oil could significantly prevent from decreasing of GSH, GST and FRAP and increasing of the Liver enzymes and lipid peroxidation after severe Acetaminophen toxicity. Also, the histopathological findings of the liver tissue was confirmed the above results. Therefore, the Golpar essential oil could remarkably protect the liver tissue against the Stress oxidative induced by Acetaminophen.

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APA: Copy

DADKHAH, A., Khalaj, gh., FATEMI, F., DINI, S., Naeege, s., & Fadaee Monfared, m.. (2016). Considering the effect of Golpar (Heracleum Persicum) essential oils on the acute hepatotoxcity induced by acetaminophen in Wistar rats. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 29(3 ), 292-306. SID. https://sid.ir/paper/248748/en

Vancouver: Copy

DADKHAH A., Khalaj gh., FATEMI F., DINI S., Naeege s., Fadaee Monfared m.. Considering the effect of Golpar (Heracleum Persicum) essential oils on the acute hepatotoxcity induced by acetaminophen in Wistar rats. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2016;29(3 ):292-306. Available from: https://sid.ir/paper/248748/en

IEEE: Copy

A. DADKHAH, gh. Khalaj, F. FATEMI, S. DINI, s. Naeege, and m. Fadaee Monfared, “Considering the effect of Golpar (Heracleum Persicum) essential oils on the acute hepatotoxcity induced by acetaminophen in Wistar rats,” JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 29, no. 3 , pp. 292–306, 2016, [Online]. Available: https://sid.ir/paper/248748/en

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