STUDY OF THE EFFECT OF IRON OXIDE NANOPARTICLES ON MOUSE TESTIS DEVELOPMENT DURING THE EMBRYONIC PERIOD IN NMRI STRAIN

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SHARIFDINI HAVVA; PARIVAR KAZEM; HAYATI RODBARI NASIM

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Journal: NOVA BIOLOGICA REPERTA Year:2017 | Volume:4 | Issue:3 Page(s): 215-225

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Title

STUDY OF THE EFFECT OF IRON OXIDE NANOPARTICLES ON MOUSE TESTIS DEVELOPMENT DURING THE EMBRYONIC PERIOD IN NMRI STRAIN

Author(s)

SHARIFDINI HAVVA | PARIVAR KAZEM | HAYATI RODBARI NASIM | Issue Writer Certificate

Keywords

NANO PARTICLESQ1

SPERMATOGENESISQ2

CRITICAL PERIODQ2

ANTIOXIDANTQ1

OXIDIATIONQ1

REDUCTIONQ1

Abstract

Of different types of bio-compatible nanoparticles, iron oxide nanoparticle has attracted attention for its applications especially in medicine and magnetic resonance imaging (MRI). We decided to study histological changes in testis and SPERMATOGENESIS in mature male mice that are affected by ironoxide nanoparticles (Fe2O3) during fetal period. In this study, the mice were divided into three experimental and two control and sham groups. Iron oxide at doses of 10, 30, 50 mg/kg were injected into pregnant mice during 10th, 12th and 14th days of the CRITICAL PERIOD of fetus testis development. After the maturation of the mice which were born, slices with the thickness of 0.06 μm were prepared from adult male testis and epididymis, stained with hematoxylin and eosin. The cells were counted, then the obtained data was analyzed with one-way ANONA and Tukey testes. The results showed that the number of epididymis sperms at the doses of 10 and 30 mg/kg, testis weight at the dose of 30 mg/kg, primary spermatocytes at the dose 10mg/kg had increased, while the testis diameter in all the three experimental groups and the volume of the testis at the dose of 50 mg/kg had decreased. Disorganization and vacuolization were observed at high doses. Passing through the cell membrane, and considering its oxidation and REDUCTION potentials, it was observed that Iron oxide nanoparticle acts as ANTIOXIDANT at low doses and shows toxicity at high doses. The fact obtained in the paper reflects the dual potential of the iron oxide nanoparticle.

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APA: Copy

SHARIFDINI, HAVVA, PARIVAR, KAZEM, & HAYATI RODBARI, NASIM. (2017). STUDY OF THE EFFECT OF IRON OXIDE NANOPARTICLES ON MOUSE TESTIS DEVELOPMENT DURING THE EMBRYONIC PERIOD IN NMRI STRAIN. NOVA BIOLOGICA REPERTA, 4(3 ), 215-225. SID. https://sid.ir/paper/250532/en

Vancouver: Copy

SHARIFDINI HAVVA, PARIVAR KAZEM, HAYATI RODBARI NASIM. STUDY OF THE EFFECT OF IRON OXIDE NANOPARTICLES ON MOUSE TESTIS DEVELOPMENT DURING THE EMBRYONIC PERIOD IN NMRI STRAIN. NOVA BIOLOGICA REPERTA[Internet]. 2017;4(3 ):215-225. Available from: https://sid.ir/paper/250532/en

IEEE: Copy

HAVVA SHARIFDINI, KAZEM PARIVAR, and NASIM HAYATI RODBARI, “STUDY OF THE EFFECT OF IRON OXIDE NANOPARTICLES ON MOUSE TESTIS DEVELOPMENT DURING THE EMBRYONIC PERIOD IN NMRI STRAIN,” NOVA BIOLOGICA REPERTA, vol. 4, no. 3 , pp. 215–225, 2017, [Online]. Available: https://sid.ir/paper/250532/en

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