Copper oxide nanoparticles toxicity on pituitary gonadal axis and spermatogenesis in male rats

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Rajabi Sajjad; NOORI ALI; SHAHBAZI FATEMEH

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:21 | Issue:3 (71) Page(s): 49-56

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Title

Copper oxide nanoparticles toxicity on pituitary gonadal axis and spermatogenesis in male rats

Author(s)

Rajabi Sajjad | NOORI ALI | SHAHBAZI FATEMEH | Issue Writer Certificate

Keywords

Copper oxide nanoparticlesQ1

GonadotropinsQ1

TestosteroneQ2

SpermatogenesisQ2

Abstract

Background and Objective: Copper oxide nanoparticles with unique properties have numerous biological applications with probably toxicity. This study was conducted to determine the toxicity of Copper oxide nanoparticles on the pituitary-gonadal axis and Spermatogenesis in male rats. Methods: In this experimental study, 40 male Wistar rats were randomly allocated into 4 groups including control group and three intervention groups which receiving the cancentration of 10, 20 and 30 mg/kg of Copper oxide nanoparticles 5 times intra-peritoneally, respectively. Blood sampling was collected first day and 15 days after the last injection. Level of Testosterone, FSH and LH were measured by ELISA method. After anesthesia and dissection of mice in each group, tissue sections of testis were prepared and stained with hematoxylin-eosin. Morphological status of Spermatogenesis process and counting of types of cells (spermatogonium, spermatocyte and spermatid) were studied by optical microscope. Results: In the first day of blood collection, a significant increase in LH and FSH level was observed at concentrations of 10 and 30 mg/kg, respectively. Also, Testosterone and FSH level decreased significantly reduced at 10 mg/kg/bw concentration compared to control (P<0. 05). In 15 days after of the last injection, level of Testosterone (P<0. 05) and LH (P<0. 05) significantly increased in concentrations of 10 and 30 mg/kg/bw respectively. Also, there was a significant reduction in level of FSH in the concentration of 10 mg/kg/bw (P<0. 05). The examination of testis tissue sections showed a significant decrease (P<0. 05) in density and number of cell types (spermatogonium, spermatocyte and spermatid) and anomalies in the Spermatogenesis process, in a dose-dependent manner. The most disturbances was seen at a concentration of 30 mg/kg/bw of Copper oxide nanoparticles. Conclusion: Copper oxide nanoparticles may interfere with the secretion of Gonadotropins and Testosterone and ultimately lead to a disruption of the Spermatogenesis process.

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Effect of Diazepam on testicular tissue parameters and spermatogenesis in rats

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APA: Copy

Rajabi, Sajjad, NOORI, ALI, & SHAHBAZI, FATEMEH. (2019). Copper oxide nanoparticles toxicity on pituitary gonadal axis and spermatogenesis in male rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 21(3 (71) ), 49-56. SID. https://sid.ir/paper/370034/en

Vancouver: Copy

Rajabi Sajjad, NOORI ALI, SHAHBAZI FATEMEH. Copper oxide nanoparticles toxicity on pituitary gonadal axis and spermatogenesis in male rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;21(3 (71) ):49-56. Available from: https://sid.ir/paper/370034/en

IEEE: Copy

Sajjad Rajabi, ALI NOORI, and FATEMEH SHAHBAZI, “Copper oxide nanoparticles toxicity on pituitary gonadal axis and spermatogenesis in male rats,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 3 (71) , pp. 49–56, 2019, [Online]. Available: https://sid.ir/paper/370034/en

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