THE PROTECTIVE EFFECT OF ZNO NANOPARTICLES ON LIVER AND IMPAIRMENTS INDUCED BY PACLITAXEL TREATMENT IN FEMALE WISTAR RAT

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MOHSENI KOUCHESFAHANI HOMA; OSTADBAGHER KASHI ATOUSA

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Journal: NOVA BIOLOGICA REPERTA Year:2016 | Volume:3 | Issue:3 Page(s): 218-227

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Title

THE PROTECTIVE EFFECT OF ZNO NANOPARTICLES ON LIVER AND IMPAIRMENTS INDUCED BY PACLITAXEL TREATMENT IN FEMALE WISTAR RAT

Author(s)

MOHSENI KOUCHESFAHANI HOMA | OSTADBAGHER KASHI ATOUSA | Issue Writer Certificate

Keywords

HISTOPATHOLOGYQ2

CHEMOTHERAPYQ2

TRANSAMINASESQ1

BILIRUBINQ1

ALKALINE PHOSPHATASEQ2

Abstract

Paclitaxel is a CHEMOTHERAPY drug inhibiting cell growth. In some studies, patients with normal liver function have experienced increase in BILIRUBIN, ALT and AST by using paclitaxel. The aim of this study was to evaluate the effect of intra-peritoneal injection of doses 5 and 10 mg/kg nZnO on the liver of rats treated with paclitaxel.35 adult female Wistar rats were divided into 7 groups including control, sham (saline injection), experimental groups1 and 2 (nZnO injection), experimental group 3 (paclitaxel injection), experimental groups 4 and 5 (nZnO and paclitaxel injection).Liver function was examined 28 days after the end of injection. Experimental group3 had large and swollen liver morphology. Most hepatocytes had dense nuclei and changed cell shape indicating of cell death. Blood test showed significant increase in the levels of ALT, AST and BILIRUBIN and decrease in the level of ALP in comparison with the control group. In experimental groups 4 and 5, cell shape alterations, increase in cell death and increase in liver markers were remarkably reduced in comparison with the experimental group 3, in a way that there were no significant differences with the control group. No significant differences were observed between the control group and experimental groups 1 and 2. According to the findings, nZnO can reduce the side effects of paclitaxel on liver tissue.

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APA: Copy

MOHSENI KOUCHESFAHANI, HOMA, & OSTADBAGHER KASHI, ATOUSA. (2016). THE PROTECTIVE EFFECT OF ZNO NANOPARTICLES ON LIVER AND IMPAIRMENTS INDUCED BY PACLITAXEL TREATMENT IN FEMALE WISTAR RAT. NOVA BIOLOGICA REPERTA, 3(3), 218-227. SID. https://sid.ir/paper/250575/en

Vancouver: Copy

MOHSENI KOUCHESFAHANI HOMA, OSTADBAGHER KASHI ATOUSA. THE PROTECTIVE EFFECT OF ZNO NANOPARTICLES ON LIVER AND IMPAIRMENTS INDUCED BY PACLITAXEL TREATMENT IN FEMALE WISTAR RAT. NOVA BIOLOGICA REPERTA[Internet]. 2016;3(3):218-227. Available from: https://sid.ir/paper/250575/en

IEEE: Copy

HOMA MOHSENI KOUCHESFAHANI, and ATOUSA OSTADBAGHER KASHI, “THE PROTECTIVE EFFECT OF ZNO NANOPARTICLES ON LIVER AND IMPAIRMENTS INDUCED BY PACLITAXEL TREATMENT IN FEMALE WISTAR RAT,” NOVA BIOLOGICA REPERTA, vol. 3, no. 3, pp. 218–227, 2016, [Online]. Available: https://sid.ir/paper/250575/en

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