Preparation of Methotrexate loaded Human Serum Albumin and its toxic effects on human glioblastoma cell

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Fallah anbohi Saeedeh; ADABI MAHDI; KHOSRAVANI MASOOD; DINARVAND RASSOUL

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Journal: NANOSCALE Year:2019 | Volume:6 | Issue:2 Page(s): 87-95

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Information Journal Paper

Title

Preparation of Methotrexate loaded Human Serum Albumin and its toxic effects on human glioblastoma cell

Author(s)

Fallah anbohi Saeedeh | ADABI MAHDI | KHOSRAVANI MASOOD | DINARVAND RASSOUL | Issue Writer Certificate

Keywords

MethotrexateQ1

AlbuminQ1

NanoparticleQ1

GlioblastomaQ1

Abstract

Methotrexate (MTX) as a chemotherapeutic agent has the potential to be used in the treatment of brain tumors, but it is less used due to insufficient penetration into the brain parenchyma. By designing nanotechnologybased systems, it can be possible to overcome these limitations. In this study, the sonication method was used to prepare MTX loaded human serum Albumin (HSA) Nanoparticles. The results indicated that MTX loaded HSA Nanoparticles have the size less than 100 nm. The obtained values for drug loading and encapsulation efficacy were 3% and 47%, respectively; and the results of thermal analysis of Nanoparticles demonstated the amorphous form of MTX in HSA. In the release profile, slow and controlled release of Nanoparticles was also observed in the neutral environment. In addition, the results indicated the decreased cytotoxic effects of MTX loaded HSA Nanoparticles in comparison with free MTX. Therefore, the proposed formulation can have high potential in drug delivery systems to Glioblastoma cells.

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APA: Copy

Fallah anbohi, Saeedeh, ADABI, MAHDI, KHOSRAVANI, MASOOD, & DINARVAND, RASSOUL. (2019). Preparation of Methotrexate loaded Human Serum Albumin and its toxic effects on human glioblastoma cell. NANOSCALE, 6(2 ), 87-95. SID. https://sid.ir/paper/257024/en

Vancouver: Copy

Fallah anbohi Saeedeh, ADABI MAHDI, KHOSRAVANI MASOOD, DINARVAND RASSOUL. Preparation of Methotrexate loaded Human Serum Albumin and its toxic effects on human glioblastoma cell. NANOSCALE[Internet]. 2019;6(2 ):87-95. Available from: https://sid.ir/paper/257024/en

IEEE: Copy

Saeedeh Fallah anbohi, MAHDI ADABI, MASOOD KHOSRAVANI, and RASSOUL DINARVAND, “Preparation of Methotrexate loaded Human Serum Albumin and its toxic effects on human glioblastoma cell,” NANOSCALE, vol. 6, no. 2 , pp. 87–95, 2019, [Online]. Available: https://sid.ir/paper/257024/en

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