EFFECT OF VITAMIN C ON LIVER INJURY AFTER TAKING METHOTREXATE IN RATS

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JAMALI BEHZAD; JAMALI SAJJAD; SHOKRI KALEHSAR NASSER

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2018 | Volume:28 | Issue:1 Page(s): 44-49

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Title

EFFECT OF VITAMIN C ON LIVER INJURY AFTER TAKING METHOTREXATE IN RATS

Author(s)

JAMALI BEHZAD | JAMALI SAJJAD | SHOKRI KALEHSAR NASSER | Issue Writer Certificate

Keywords

ASCORBIC ACIDQ2

LIVERQ2

DAMAGEQ2

METHOTREXATEQ2

RATQ2

Abstract

Background: METHOTREXATE is a folic acid antagonist which is widely used as a cytotoxic chemotherapeutic agent for leukemia and other malignancies. It causes structural and functional DAMAGEs in LIVER. The aim of this study was to determine the effects of vitamin C on the LIVER enzymes, including alanine amino transferase (ALT) and spartate amino transferase (AST), and also LIVER tissue DAMAGEs induces bytaking METHOTREXATE. Materials and methods: In this study, 30 RATs were divided into three groups. Group 1 (control group) received normal saline (0. 9%), intraperitoneally, for 10 consecutive days. Group 2 were given METHOTREXATE (20mg/kg) intraperitoneally for 10 consecutive days. Group 3 received METHOTREXATE with vitamin C (25mg/kg) intraperitoneally for 10 consecutive days. After 10 days, all animals were anaesthetized and blood serum were collected for biochemical analysis. After cervical dislocation, the LIVER tissue samples were taken in order to histological evaluation by light microscopy. Results: Serum levels of AST and ALT were significantly lower in group of METHOTREXATE and vitamin C compared to METHOTREXATE group (p<0. 05). The amount of LIVER tissue DAMAGEs in group received METHOTREXATE and vitamin C was lower than the group received only METHOTREXATE (P<0. 05). Conclusion: The results of this study show that vitamin C may have a beneficial role in preventing LIVER DAMAGE caused by METHOTREXATE and thus it could be considered potential role in clinical applications.

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APA: Copy

JAMALI, BEHZAD, JAMALI, SAJJAD, & SHOKRI KALEHSAR, NASSER. (2018). EFFECT OF VITAMIN C ON LIVER INJURY AFTER TAKING METHOTREXATE IN RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 28(1 ), 44-49. SID. https://sid.ir/paper/98917/en

Vancouver: Copy

JAMALI BEHZAD, JAMALI SAJJAD, SHOKRI KALEHSAR NASSER. EFFECT OF VITAMIN C ON LIVER INJURY AFTER TAKING METHOTREXATE IN RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2018;28(1 ):44-49. Available from: https://sid.ir/paper/98917/en

IEEE: Copy

BEHZAD JAMALI, SAJJAD JAMALI, and NASSER SHOKRI KALEHSAR, “EFFECT OF VITAMIN C ON LIVER INJURY AFTER TAKING METHOTREXATE IN RATS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 28, no. 1 , pp. 44–49, 2018, [Online]. Available: https://sid.ir/paper/98917/en

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