INVESTIGATION OF EFFECTIVE FACTORS ON SIZE OF POLYMER/PROTEIN NANOPARTICLES: AN ARTIFICIAL NEURAL NETWORKS STUDY

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BAHARIFAR H.; AMANI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: NANOSCALE Year:2015 | Volume:2 | Issue:1 Page(s): 13-17

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Title

INVESTIGATION OF EFFECTIVE FACTORS ON SIZE OF POLYMER/PROTEIN NANOPARTICLES: AN ARTIFICIAL NEURAL NETWORKS STUDY

Author(s)

BAHARIFAR H. | AMANI A. | Issue Writer Certificate

Keywords

ALBUMINQ1

SIZEQ2

ARTIFICIAL NEURAL NETWORKSQ2

CHITOSANQ2

Abstract

Size is one of the most important physical factors of nanoparticles (NPs). The SIZE of the NPs can be effective in application of particles, especially in designing of drug delivery systems. NPs SIZE could regulate blood half-life, immunogenicity and toxicity of them. So determination factors affecting the SIZE can be very helpful in various applications. In this study the influence of various factors, including CHITOSAN concentration, pH and reaction time (as independent variables), on the self-assembled NPs were investigated. ARTIFICIAL NEURAL NETWORKS were used to study the relationship between the independent and dependent variables. The results showed that CHITOSAN concentration is the most important factor and has a direct effect on SIZE. pH and reaction time have slight effect on SIZE. Increasing pH would decrease the SIZE but increasing pH would lead to increasing SIZE. In total for preparation of CHITOSAN/ALBUMIN NPs in desired SIZE, polymer concentration, pH and reaction time must be adjusted.

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APA: Copy

BAHARIFAR, H., & AMANI, A.. (2015). INVESTIGATION OF EFFECTIVE FACTORS ON SIZE OF POLYMER/PROTEIN NANOPARTICLES: AN ARTIFICIAL NEURAL NETWORKS STUDY. NANOSCALE, 2(1), 13-17. SID. https://sid.ir/paper/257032/en

Vancouver: Copy

BAHARIFAR H., AMANI A.. INVESTIGATION OF EFFECTIVE FACTORS ON SIZE OF POLYMER/PROTEIN NANOPARTICLES: AN ARTIFICIAL NEURAL NETWORKS STUDY. NANOSCALE[Internet]. 2015;2(1):13-17. Available from: https://sid.ir/paper/257032/en

IEEE: Copy

H. BAHARIFAR, and A. AMANI, “INVESTIGATION OF EFFECTIVE FACTORS ON SIZE OF POLYMER/PROTEIN NANOPARTICLES: AN ARTIFICIAL NEURAL NETWORKS STUDY,” NANOSCALE, vol. 2, no. 1, pp. 13–17, 2015, [Online]. Available: https://sid.ir/paper/257032/en

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