Nano-Selenium Loading on Structure of Lactobacillus and Evaluating its Antimicrobial Potency to Make Anti-Diarrhea Drug-Supplement

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Cheraghi Saray s.; HOSSEINKHANI A.; TAGHIZADEH A.; MOHAMMADZADEH H.; HAMISHEHKAR H.

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Journal: NANOSCALE Year:2019 | Volume:6 | Issue:1 Page(s): 19-28

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Title

Nano-Selenium Loading on Structure of Lactobacillus and Evaluating its Antimicrobial Potency to Make Anti-Diarrhea Drug-Supplement

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Keywords

Nano-Selenium ParticleQ1

LactobacillusQ2

AntimicrobialQ1

Escherichia coliQ1

Abstract

Escherichia coli (E. coli) is the most important species that causes dysentery. Present study was conducted to investigate the synergistic Antimicrobial effects of Nano-selenium and Lactobacillus on E. coli to suggest anti-diarrhea bio-drug. The Antimicrobial effects of experimental treatments against E. coli were evaluated by disk diffusion and well diffusion methods as a measure of the growth inhibition zone. Moreover, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by microdilution method. The results of the well and disk diffusion methods showed that in both tests, the highest growth inhibition zone of the "Nano selenium-loaded Lactobacillus" treatment on the standard strain of E. coli was 23/6 and 23/36 mm respectively. The results of MIC and MBC determination showed that in all experimental periods, "Nano selenium-loaded Lactobacillus" and "Nano-selenium + Lactobacillus" treatments with 590/7 and 615/38 μ g/ml for MIC and 955/32 and 1195/67 μ g/ml for MBC had the lowest amounts compared to other treatments (P<0. 05). The results of this experiment confirmed the anti-diarrhea ability of "Nano selenium-loaded Lactobacillus" treatment. Therefore, provided that this test be repeated in future studies and ensured the accuracy of these results, manufacturing of bio-drug with this formulation may be advised for prevention or treatment of diarrheal disease.

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APA: Copy

Cheraghi Saray, s., HOSSEINKHANI, A., TAGHIZADEH, A., MOHAMMADZADEH, H., & HAMISHEHKAR, H.. (2019). Nano-Selenium Loading on Structure of Lactobacillus and Evaluating its Antimicrobial Potency to Make Anti-Diarrhea Drug-Supplement. NANOSCALE, 6(1 ), 19-28. SID. https://sid.ir/paper/257054/en

Vancouver: Copy

Cheraghi Saray s., HOSSEINKHANI A., TAGHIZADEH A., MOHAMMADZADEH H., HAMISHEHKAR H.. Nano-Selenium Loading on Structure of Lactobacillus and Evaluating its Antimicrobial Potency to Make Anti-Diarrhea Drug-Supplement. NANOSCALE[Internet]. 2019;6(1 ):19-28. Available from: https://sid.ir/paper/257054/en

IEEE: Copy

s. Cheraghi Saray, A. HOSSEINKHANI, A. TAGHIZADEH, H. MOHAMMADZADEH, and H. HAMISHEHKAR, “Nano-Selenium Loading on Structure of Lactobacillus and Evaluating its Antimicrobial Potency to Make Anti-Diarrhea Drug-Supplement,” NANOSCALE, vol. 6, no. 1 , pp. 19–28, 2019, [Online]. Available: https://sid.ir/paper/257054/en

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