Investigation of the Structural Properties of Dopamine-Loaded Poly(butyl cyanoacrylate) Nanosystem

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Jahansooz Fatemeh; Ebrahimi hosseinzadeh Bahman; HATAMIAN ZARMI ASHRAFALSADAT; Shahpasand Koorosh; Motamedi Elahe

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Journal: APPLIED RESEARCH IN CHEMICAL POLYMER ENGINEERING Year:2020 | Volume:3 | Issue:4 Page(s): 73-83

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Title

Investigation of the Structural Properties of Dopamine-Loaded Poly(butyl cyanoacrylate) Nanosystem

Author(s)

Keywords

Poly(butyl cyanoacrylate)

Dopamine

Parkinson’s disease

Nanosystem

Polymerization

Abstract

Parkinson’ s disease (PD) is a neurodegenerative disorder with no treatment due to the blood-brain barrier (BBB) existence. However, if Dopamine (DA) molecule is able to pass through the BBB, it can be considered as a cure for PD. The aim of this study was to prepare biodegradable nanoparticles (NPs) carrying DA for crossing the BBB, using ion Polymerization and solvent. Particle size and size distribution, zeta potential, entrapment efficiency, and in vitro drug release behavior were determined at pH=7. The drug-loaded nanoparticles were found to be spherical with fluffy exterior, average size of 110 nm and zeta potential of-7. 61 mV. Fourier-transform infrared (FTIR) spectroscopy (FTIR) verified Polymerization of butyl cyanoacrylate monomers and physical encapsulation of DA in the polymer, poly(butyl cyanoacrylate) (PBCA). Loading and drug encapsulation efficiencies were 35 and 52 w/v %, respectively, characterized by high performance liquid chromatography (HPLC). The in-vitro drug release profile of DA-loaded PBCA nanoparticles exhibited a gradual release of more than 20 ٪ w/w of the drug after 51 h. Investigation of in-vivo release of fluorescein isothiocyanate from nanocarrier as a model drug for Dopamine in brain proved its gradual release using fluorescent microscopy. In this study, PBCA nanoparticles were successfully introduced as a delivery system for the hydrophilic DA, providing a promising approach for improvement of PD.

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APA: Copy

Jahansooz, Fatemeh, Ebrahimi hosseinzadeh, Bahman, HATAMIAN ZARMI, ASHRAFALSADAT, Shahpasand, Koorosh, & Motamedi, Elahe. (2020). Investigation of the Structural Properties of Dopamine-Loaded Poly(butyl cyanoacrylate) Nanosystem. APPLIED RESEARCH IN CHEMICAL POLYMER ENGINEERING, 3(4 ), 73-83. SID. https://sid.ir/paper/267776/en

Vancouver: Copy

Jahansooz Fatemeh, Ebrahimi hosseinzadeh Bahman, HATAMIAN ZARMI ASHRAFALSADAT, Shahpasand Koorosh, Motamedi Elahe. Investigation of the Structural Properties of Dopamine-Loaded Poly(butyl cyanoacrylate) Nanosystem. APPLIED RESEARCH IN CHEMICAL POLYMER ENGINEERING[Internet]. 2020;3(4 ):73-83. Available from: https://sid.ir/paper/267776/en

IEEE: Copy

Fatemeh Jahansooz, Bahman Ebrahimi hosseinzadeh, ASHRAFALSADAT HATAMIAN ZARMI, Koorosh Shahpasand, and Elahe Motamedi, “Investigation of the Structural Properties of Dopamine-Loaded Poly(butyl cyanoacrylate) Nanosystem,” APPLIED RESEARCH IN CHEMICAL POLYMER ENGINEERING, vol. 3, no. 4 , pp. 73–83, 2020, [Online]. Available: https://sid.ir/paper/267776/en

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