PREPARATION AND EVALUATION OF THE PROPERTIES OF CARBOPLATIN-LOADED POLY BUTYL CYANOACRYLATE NANOPARTICLE

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DASHTI RAHMAT ABADI FATEMEH; ABEDI ANITA; EBRAHIMI SHAHMABADI HASAN; KOOHI MOFTAKHARI ESFAHANI MAEDEH; ALAVI SEYED EBRAHIM; MARZBAN ADEL; AKBARZADEH AZIM

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2014 | Volume:5 | Issue:15 Page(s): 43-49

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Title

PREPARATION AND EVALUATION OF THE PROPERTIES OF CARBOPLATIN-LOADED POLY BUTYL CYANOACRYLATE NANOPARTICLE

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Keywords

POLY BUTYL CYANOACRYLATEQ2

DRUG DELIVERYQ1

POLYMERIZATION EMULSIONQ2

CARBOPLATINQ2

CYTOTOXICITYQ2

Abstract

Aim and Background: CARBOPLATIN as an anticancer agent belongs to platinum family drugs. Along with anticancer functionalities, this drug may have some side effects. Targeted and selective prescriptions of drugs reduce their side effects. Nanotechnology-based DRUG DELIVERY systems are available approaches to overcome this problem. In this study, CARBOPLATIN was loaded on POLY BUTYL CYANOACRYLATE nanoparticles and then its features were evaluated.Materials and Methods: CARBOPLATIN was loaded into nanoparticle during polymerization of monomer. Monomer was polymerized by emulsion polymerization technique. To determine amount of loaded drug on nanoparticle, spectrophotometery method was used. Evaluation of the CYTOTOXICITY effects of free form of drug and CARBOPLATIN-loaded nanoparticle were performed on MCF-7 cell line using MTT assay.Results: size and zeta potential of CARBOPLATIN-loaded nanoparticles were found to be 319 nm and -7 mv. Loading percentage of CARBOPLATIN on nanoparticles was estimated 6%. Evaluation of CYTOTOXICITY effects shown survival rate due to CARBOPLATIN and CARBOPLATIN-loaded nanoparticle at concentration 20 macro molar (p<0.01) were estimated 80±0.6% and 84±0.6%, respectively. These values at the concentration of 160 macro molar (p<0.01) were estimated %44±0.5 and %51±0.2, respectively.Conclusion: Probably, due to low loading efficiency, CYTOTOXICITY effects of CARBOPLATIN-loaded nanoparticle were decreased in comparison with free form. Further studies were needed to construct suitable CARBOPLATIN-loaded poly butylcyanoacrylate nanoparticle. In this way miniemulsion polymerization could be recruited.

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APA: Copy

DASHTI RAHMAT ABADI, FATEMEH, ABEDI, ANITA, EBRAHIMI SHAHMABADI, HASAN, KOOHI MOFTAKHARI ESFAHANI, MAEDEH, ALAVI, SEYED EBRAHIM, MARZBAN, ADEL, & AKBARZADEH, AZIM. (2014). PREPARATION AND EVALUATION OF THE PROPERTIES OF CARBOPLATIN-LOADED POLY BUTYL CYANOACRYLATE NANOPARTICLE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 5(15), 43-49. SID. https://sid.ir/paper/204378/en

Vancouver: Copy

DASHTI RAHMAT ABADI FATEMEH, ABEDI ANITA, EBRAHIMI SHAHMABADI HASAN, KOOHI MOFTAKHARI ESFAHANI MAEDEH, ALAVI SEYED EBRAHIM, MARZBAN ADEL, AKBARZADEH AZIM. PREPARATION AND EVALUATION OF THE PROPERTIES OF CARBOPLATIN-LOADED POLY BUTYL CYANOACRYLATE NANOPARTICLE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2014;5(15):43-49. Available from: https://sid.ir/paper/204378/en

IEEE: Copy

FATEMEH DASHTI RAHMAT ABADI, ANITA ABEDI, HASAN EBRAHIMI SHAHMABADI, MAEDEH KOOHI MOFTAKHARI ESFAHANI, SEYED EBRAHIM ALAVI, ADEL MARZBAN, and AZIM AKBARZADEH, “PREPARATION AND EVALUATION OF THE PROPERTIES OF CARBOPLATIN-LOADED POLY BUTYL CYANOACRYLATE NANOPARTICLE,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 5, no. 15, pp. 43–49, 2014, [Online]. Available: https://sid.ir/paper/204378/en

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