DESIGN AND SYNTHESIS OF COUMARIN SUBSTITUTED OXATHIADIAZOLONE DERIVATIVES HAVING ANTI-INFLAMMATORY ACTIVITY POSSIBLY THROUGH P38 MAP KINASE INHIBITION

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BANSAL Y.; RATRA S.; BANSAL G.; SINGH I.; ABOUL ENEIN H.Y.

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Journal: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS) Year:2009 | Volume:6 | Issue:3 Page(s): 504-509

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Title

DESIGN AND SYNTHESIS OF COUMARIN SUBSTITUTED OXATHIADIAZOLONE DERIVATIVES HAVING ANTI-INFLAMMATORY ACTIVITY POSSIBLY THROUGH P38 MAP KINASE INHIBITION

Author(s)

Keywords

OXATHIADIAZOLONE

COUMARIN

MAP KINASE

SUPERIMPOSITION

ISOXAZOLONE

PYRAZOLONE

Abstract

Compounds containing OXATHIADIAZOLONE nucleus bearing substituted COUMARIN ring were designed and synthesized while retaining the pharmacophores required for binding with p38 MAP KINASE. A four-step synthetic scheme was employed for the synthesis of 7-methoxy-4-(3 ×-substituted-2΄-oxo-1 ×, 2 ×,3 ×, 5 × -oxathiadiazol-4×-yl)-coumarin. The reactions were monitored by TLC and structures of the intermediates and the target compounds were ascertained by IR, NMR, Mass spectral data. The compounds were found to possess anti-inflammatory activity comparable to indomethacin. SUPERIMPOSITION studies of the target compounds with the lead p38 kinase inhibitors suggested that anti-inflammatory activity of the target compounds may be due to p38 MAP KINASE inhibition. It was also suggested that methoxy group on COUMARIN nucleus may improve the binding profile with p38 MAP KINASE.

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APA: Copy

BANSAL, Y., RATRA, S., BANSAL, G., SINGH, I., & ABOUL ENEIN, H.Y.. (2009). DESIGN AND SYNTHESIS OF COUMARIN SUBSTITUTED OXATHIADIAZOLONE DERIVATIVES HAVING ANTI-INFLAMMATORY ACTIVITY POSSIBLY THROUGH P38 MAP KINASE INHIBITION. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 6(3), 504-509. SID. https://sid.ir/paper/282332/en

Vancouver: Copy

BANSAL Y., RATRA S., BANSAL G., SINGH I., ABOUL ENEIN H.Y.. DESIGN AND SYNTHESIS OF COUMARIN SUBSTITUTED OXATHIADIAZOLONE DERIVATIVES HAVING ANTI-INFLAMMATORY ACTIVITY POSSIBLY THROUGH P38 MAP KINASE INHIBITION. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2009;6(3):504-509. Available from: https://sid.ir/paper/282332/en

IEEE: Copy

Y. BANSAL, S. RATRA, G. BANSAL, I. SINGH, and H.Y. ABOUL ENEIN, “DESIGN AND SYNTHESIS OF COUMARIN SUBSTITUTED OXATHIADIAZOLONE DERIVATIVES HAVING ANTI-INFLAMMATORY ACTIVITY POSSIBLY THROUGH P38 MAP KINASE INHIBITION,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 6, no. 3, pp. 504–509, 2009, [Online]. Available: https://sid.ir/paper/282332/en

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