DESIGN AND SYNTHESIS OF NOVEL DINUCLEOTIDE ANALOGS

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VALIYEV F.; ABBASOV V.; LIU H.J.; TSAI F.Y.

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ISSN: 2588-4824

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Journal: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS) Year:2010 | Volume:7 | Issue:3 Page(s): 597-602

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Title

DESIGN AND SYNTHESIS OF NOVEL DINUCLEOTIDE ANALOGS

Author(s)

VALIYEV F. | ABBASOV V. | LIU H.J. | TSAI F.Y. | Issue Writer Certificate

Keywords

NUCLEOSIDES

DINUCLEOTIDES

ANTIVIRALS

ANTI-HIV

PHOSPHOROTRIESTERS

Abstract

Syntheses of dinucleotide analogs, (S,R) cis-(4-((4-amino-2-oxopyrimidin-1(2H)-yl)methyl)-1,3-dioxolan-2-yl)methyl (2R,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl hydrogen phosphate (5a) and (S,R) cis-(5-((4-amino-2-oxopyrimidin-1(2H)-yl)methyl)-1,3-oxathiolan-2-yl)methyl (2R,3R,5R)-2-(hydroxymethyl)-5- (5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl hydrogen phosphate (5b), were accomplished by the use of a new strategy. The use of phenyldichlorophosphate (Method A) as the coupling reagent was shown to possess superiority relative to the reported use of di(1H-benzo[d][1,2,3]triazol-1-yl)phenyl phosphonate (Method B).

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APA: Copy

VALIYEV, F., ABBASOV, V., LIU, H.J., & TSAI, F.Y.. (2010). DESIGN AND SYNTHESIS OF NOVEL DINUCLEOTIDE ANALOGS. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 7(3), 597-602. SID. https://sid.ir/paper/282473/en

Vancouver: Copy

VALIYEV F., ABBASOV V., LIU H.J., TSAI F.Y.. DESIGN AND SYNTHESIS OF NOVEL DINUCLEOTIDE ANALOGS. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2010;7(3):597-602. Available from: https://sid.ir/paper/282473/en

IEEE: Copy

F. VALIYEV, V. ABBASOV, H.J. LIU, and F.Y. TSAI, “DESIGN AND SYNTHESIS OF NOVEL DINUCLEOTIDE ANALOGS,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 7, no. 3, pp. 597–602, 2010, [Online]. Available: https://sid.ir/paper/282473/en

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