ON-LINE MONITORING OF A CONTINUOUS PHARMACEUTICAL PROCESS USING PARALLEL FACTOR ANALYSIS AND UNFOLDING MULTIVARIATE STATISTICAL PROCESS CONTROL REPRESENTATION

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KOMPANY ZAREH M.

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Journal Paper

Paper Information

Journal: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS) Year:2011 | Volume:8 | Issue:1 Page(s): 209-222

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Information Journal Paper

Title

ON-LINE MONITORING OF A CONTINUOUS PHARMACEUTICAL PROCESS USING PARALLEL FACTOR ANALYSIS AND UNFOLDING MULTIVARIATE STATISTICAL PROCESS CONTROL REPRESENTATION

Author(s)

KOMPANY ZAREH M. | Issue Writer Certificate

Keywords

MULTIWAY ON-LINE CONTINUOUS PROCESS MONITORING

PARALLEL FACTOR ANALYSIS

UNFOLDING MULTIVARIATE STATISTICAL PROCESS CONTROL

FAULT DETECTION

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

Abstract

On-line HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) was used to monitor steady state reactions in three reactors (K=3) over 48.0 h. Different numbers of chromatograms, with J=1981 retention time points, were recorded for each of the three reactors. Peaks for each chromatogram were baseline corrected and aligned using correlation optimized warping (COW). To make a complete three-way data set of I=266 chromatograms a cubic Hermite interpolation was performed. The applied bilinear multivariate statistical process control (MSPC) method included the unfolding PCA and the trilinear technique was PARAFAC.Unfolding in reactor (K) mode was the most informative. D-charts and Q-charts were applied to the data to determine samples which were out of control. Confidence limits were then applied to the D and Q-charts and variables with different behaviours from that encapsulated within the reference data set were located. Both bilinear and trilinear methods were found to be useful for process analysis.

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APA: Copy

KOMPANY ZAREH, M.. (2011). ON-LINE MONITORING OF A CONTINUOUS PHARMACEUTICAL PROCESS USING PARALLEL FACTOR ANALYSIS AND UNFOLDING MULTIVARIATE STATISTICAL PROCESS CONTROL REPRESENTATION. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 8(1), 209-222. SID. https://sid.ir/paper/282537/en

Vancouver: Copy

KOMPANY ZAREH M.. ON-LINE MONITORING OF A CONTINUOUS PHARMACEUTICAL PROCESS USING PARALLEL FACTOR ANALYSIS AND UNFOLDING MULTIVARIATE STATISTICAL PROCESS CONTROL REPRESENTATION. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2011;8(1):209-222. Available from: https://sid.ir/paper/282537/en

IEEE: Copy

M. KOMPANY ZAREH, “ON-LINE MONITORING OF A CONTINUOUS PHARMACEUTICAL PROCESS USING PARALLEL FACTOR ANALYSIS AND UNFOLDING MULTIVARIATE STATISTICAL PROCESS CONTROL REPRESENTATION,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 8, no. 1, pp. 209–222, 2011, [Online]. Available: https://sid.ir/paper/282537/en

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