EFFECTIVE SEPARATION AND SIMULTANEOUS DETECTION OF GATIFLOXACIN, AMINOMETHYLBENZOIC ACID, CEFAZOLIN AND CEFMINOX IN HUMAN URINE BY CAPILLARY ZONE ELECTROPHORESIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SUN H.; WEI L.; ZUO Y.; WU Y.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS) Year:2011 | Volume:8 | Issue:4 Page(s): 1043-1051

Download Full-Text

View:

442

Download:

216

Cites:

Information Journal Paper

Title

EFFECTIVE SEPARATION AND SIMULTANEOUS DETECTION OF GATIFLOXACIN, AMINOMETHYLBENZOIC ACID, CEFAZOLIN AND CEFMINOX IN HUMAN URINE BY CAPILLARY ZONE ELECTROPHORESIS

Author(s)

SUN H. | WEI L. | ZUO Y. | WU Y. | Issue Writer Certificate

Keywords

CAPILLARY ZONE ELECTROPHORESIS

GATIFLOXACIN

P -AMINOMETHYLBENZOIC ACID

CEFAZOLIN

CEFMINOX

HUMAN URINE

Abstract

Gatifloxacin (GAFX), P -aminomethylbezoic acid (PAMBA), CEFAZOLIN (CFZL) and CEFMINOX (CMNX) can be combined and administered perorally or intravenously, and are excreted mainly into the urine. A novel CAPILLARY ZONE ELECTROPHORESIS (CZE) method was developed, for the first time, for an effective separation and simultaneous determination of the said four drugs in HUMAN URINE. The electrophoresis conditions were investigated and optimized. A 25 mM borate buffer (pH 9.2) was used and the peak area was determined with UV detection. Under optimal conditions, the four drugs can be separated effectively. Good linearity was achieved with the correlation coefficients (r2) of>0.999. The limit of detection (LOD) for PAMBA, GAFX, CFZL and CMNX was 5.8, 3.9, 7.8 and 15.0 mg ml-1, respectively. Their average recovery in HUMAN URINE was 93.2, 98.3, 108 and 92.7%, respectively, with the RSDs ranging from 1.0% to 3.5%. The proposed method is simple, rapid and accurate, and provides the sensitivity and linearity necessary for the selective and simultaneous analysis of the test drugs in HUMAN URINE at clinically relevant concentrations.

Cites

No record.

References

No record.

Cite

APA: Copy

SUN, H., WEI, L., ZUO, Y., & WU, Y.. (2011). EFFECTIVE SEPARATION AND SIMULTANEOUS DETECTION OF GATIFLOXACIN, AMINOMETHYLBENZOIC ACID, CEFAZOLIN AND CEFMINOX IN HUMAN URINE BY CAPILLARY ZONE ELECTROPHORESIS. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 8(4), 1043-1051. SID. https://sid.ir/paper/282639/en

Vancouver: Copy

SUN H., WEI L., ZUO Y., WU Y.. EFFECTIVE SEPARATION AND SIMULTANEOUS DETECTION OF GATIFLOXACIN, AMINOMETHYLBENZOIC ACID, CEFAZOLIN AND CEFMINOX IN HUMAN URINE BY CAPILLARY ZONE ELECTROPHORESIS. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2011;8(4):1043-1051. Available from: https://sid.ir/paper/282639/en

IEEE: Copy

H. SUN, L. WEI, Y. ZUO, and Y. WU, “EFFECTIVE SEPARATION AND SIMULTANEOUS DETECTION OF GATIFLOXACIN, AMINOMETHYLBENZOIC ACID, CEFAZOLIN AND CEFMINOX IN HUMAN URINE BY CAPILLARY ZONE ELECTROPHORESIS,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 8, no. 4, pp. 1043–1051, 2011, [Online]. Available: https://sid.ir/paper/282639/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops