مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

NOVEL 2,2’-BIPYRIDINE PALLADIUM(II) COMPLEXES WITH GLYCINE DERIVATIVES: SYNTHESIS, CHARACTERIZATION, CYTOTOXIC ASSAYS AND DNA-BINDING STUDIES

Pages

  1001-1011

Abstract

 The two water-soluble designed palladium (II) complexes, [Pd(bpy)(pip-Ac)] NO3 and [Pd(bpy)(mor-Ac)]NO3, (where bpy is 2,2’-bipyridine, pip-Ac is 1-piperidineacetato and mor-Ac is 4-morpholineacetato) have been synthesized and characterized by elemental analyses, molar conductivity measurements and spectroscopic methods (FT-IR, 1H NMR, UV–Vis). The complexes have been tested for in vitro cytotoxic activity against human breast cancer cell line, T47D. The binding of these complexes with DNA has been investigated by absorption spectroscopy, fluorescence titration spectra, EB displacement and gel chromatography. The results suggest that the complexes can bind to DNA cooperatively through a static mechanism at low concentrations (~0.57 mM). The thermodynamic parameters indicated that the van der Waals and hydrogen binding might play a major role in the interaction of these complexes with DNA.

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    APA: Copy

    SAEIDIFAR, MARYAM, MANSOURI TORSHIZI, HASSAN, DIVSALAR, ADELEH, & SABOURY, ALI AKBAR. (). . , (), -. SID. https://sid.ir/paper/282885/en

    Vancouver: Copy

    SAEIDIFAR MARYAM, MANSOURI TORSHIZI HASSAN, DIVSALAR ADELEH, SABOURY ALI AKBAR. . [Internet]. ;():-. Available from: https://sid.ir/paper/282885/en

    IEEE: Copy

    MARYAM SAEIDIFAR, HASSAN MANSOURI TORSHIZI, ADELEH DIVSALAR, and ALI AKBAR SABOURY, “,” , vol. , no. , pp. –, , [Online]. Available: https://sid.ir/paper/282885/en

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    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
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