SYNTHESIS, CHARACTERIZATION, LIPOXYGENASE INHIBITORY ACTIVITY AND IN SILICO MOLECULAR DOCKING OF BIARYL BIS (BENZENESULFONAMIDE) AND INDOL-3-YL-HYDRAZIDE DERIVATIVES

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MUTAHIR SADAF; YAR MUHAMMAD; KHAN MUHAMMAD ASIM; ULLAH NISAR; SHAHZAD SOHAIL ANJUM; KHAN ISLAM ULLAH; MEHMOOD RANA ATIF; ASHRAF MUHAMMAD; NASAR RUMANA; PONTIKI ELENI

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Journal: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS) Year:2015 | Volume:12 | Issue:6 Page(s): 1123-1130

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Title

SYNTHESIS, CHARACTERIZATION, LIPOXYGENASE INHIBITORY ACTIVITY AND IN SILICO MOLECULAR DOCKING OF BIARYL BIS (BENZENESULFONAMIDE) AND INDOL-3-YL-HYDRAZIDE DERIVATIVES

Author(s)

Keywords

ARACHIDONIC ACID

LOX INHIBITORS

BAICALEIN

INDOLE DERIVATIVES

PROTEIN 1RRH

Abstract

In this paper, we have screened a library of two different series of compounds to identify potent lipoxygenase (LOX) inhibitors. A number of new biphenyl bis (benzenesulfonamides) 2–3, indol-3-yl-benzenesulfonyl and acetohydrazides 4-5 and indol-3-yl-hydrazinecarboxylate 6 were synthesized and evaluated in vitro for LOX inhibitory activity. Compounds biphenyl bis (benzenesulfonamide) 2aand indol-3-yl-benzenesulfonylhydrazide 4e presented the best anti-LOX activity within these series with IC50 values 96.31±0.18 and 81.21±2.14 mM, respectively. The results were confirmed with docking studies.

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APA: Copy

MUTAHIR, SADAF, YAR, MUHAMMAD, KHAN, MUHAMMAD ASIM, ULLAH, NISAR, SHAHZAD, SOHAIL ANJUM, KHAN, ISLAM ULLAH, MEHMOOD, RANA ATIF, ASHRAF, MUHAMMAD, NASAR, RUMANA, & PONTIKI, ELENI. (2015). SYNTHESIS, CHARACTERIZATION, LIPOXYGENASE INHIBITORY ACTIVITY AND IN SILICO MOLECULAR DOCKING OF BIARYL BIS (BENZENESULFONAMIDE) AND INDOL-3-YL-HYDRAZIDE DERIVATIVES. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 12(6), 1123-1130. SID. https://sid.ir/paper/283111/en

Vancouver: Copy

MUTAHIR SADAF, YAR MUHAMMAD, KHAN MUHAMMAD ASIM, ULLAH NISAR, SHAHZAD SOHAIL ANJUM, KHAN ISLAM ULLAH, MEHMOOD RANA ATIF, ASHRAF MUHAMMAD, NASAR RUMANA, PONTIKI ELENI. SYNTHESIS, CHARACTERIZATION, LIPOXYGENASE INHIBITORY ACTIVITY AND IN SILICO MOLECULAR DOCKING OF BIARYL BIS (BENZENESULFONAMIDE) AND INDOL-3-YL-HYDRAZIDE DERIVATIVES. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2015;12(6):1123-1130. Available from: https://sid.ir/paper/283111/en

IEEE: Copy

SADAF MUTAHIR, MUHAMMAD YAR, MUHAMMAD ASIM KHAN, NISAR ULLAH, SOHAIL ANJUM SHAHZAD, ISLAM ULLAH KHAN, RANA ATIF MEHMOOD, MUHAMMAD ASHRAF, RUMANA NASAR, and ELENI PONTIKI, “SYNTHESIS, CHARACTERIZATION, LIPOXYGENASE INHIBITORY ACTIVITY AND IN SILICO MOLECULAR DOCKING OF BIARYL BIS (BENZENESULFONAMIDE) AND INDOL-3-YL-HYDRAZIDE DERIVATIVES,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 12, no. 6, pp. 1123–1130, 2015, [Online]. Available: https://sid.ir/paper/283111/en

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