SYNTHESIS OF NOVEL 3-SUBSTITUTED-5H-BENZO [5, 6] [1, 4]THIAZINO[3, 2-E] [1, 2, 4]TRIAZINES AND THEIR 15-LIPOXYGENASE INHIBITORY ACTIVITY

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MOHAMMADI ALI; ESHGHI HOSSEIN; BAKAVOLI MEHDI; HADIZADEH FARZIN; MORADI HASSANALI

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Journal: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS) Year:2016 | Volume:13 | Issue:8 Page(s): 0-0

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Title

SYNTHESIS OF NOVEL 3-SUBSTITUTED-5H-BENZO [5, 6] [1, 4]THIAZINO[3, 2-E] [1, 2, 4]TRIAZINES AND THEIR 15-LIPOXYGENASE INHIBITORY ACTIVITY

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Keywords

FUSED BENZOTHIAZINES15-LIPOXYGENASEDOCKINGMOLECULAR MODELING TRIAZINES

Abstract

A new group of 3-substituted-5H-benzo[5,6] [1, 4] thiazino[3, 2-e] [1 2, 4]triazines was designed, synthesized and evaluated as inhibitors of 15-lipoxygenase (15-LO), and the results were compared with those of standard ligand 4-methyl-2-(4-methylpiperazin-1-yl) pyrimido[4, 5-b] [1, 4] benzothiazine (4-MMPB). Among the newly designed ligands, compound 9e showed the best IC50 of 15-LO inhibition (IC50 = 38 mM). The docking calculations were performed in MOE software based on the function of force-field scoring, in order to study the interaction of these new compounds and standard ligand with 15-LO. The docking study implied that these ligands have hydrogen bond interaction with the residue of active site of 15-LO.

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APA: Copy

MOHAMMADI, ALI, ESHGHI, HOSSEIN, BAKAVOLI, MEHDI, HADIZADEH, FARZIN, & MORADI, HASSANALI. (2016). SYNTHESIS OF NOVEL 3-SUBSTITUTED-5H-BENZO [5, 6] [1, 4]THIAZINO[3, 2-E] [1, 2, 4]TRIAZINES AND THEIR 15-LIPOXYGENASE INHIBITORY ACTIVITY. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 13(8), 0-0. SID. https://sid.ir/paper/283196/en

Vancouver: Copy

MOHAMMADI ALI, ESHGHI HOSSEIN, BAKAVOLI MEHDI, HADIZADEH FARZIN, MORADI HASSANALI. SYNTHESIS OF NOVEL 3-SUBSTITUTED-5H-BENZO [5, 6] [1, 4]THIAZINO[3, 2-E] [1, 2, 4]TRIAZINES AND THEIR 15-LIPOXYGENASE INHIBITORY ACTIVITY. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2016;13(8):0-0. Available from: https://sid.ir/paper/283196/en

IEEE: Copy

ALI MOHAMMADI, HOSSEIN ESHGHI, MEHDI BAKAVOLI, FARZIN HADIZADEH, and HASSANALI MORADI, “SYNTHESIS OF NOVEL 3-SUBSTITUTED-5H-BENZO [5, 6] [1, 4]THIAZINO[3, 2-E] [1, 2, 4]TRIAZINES AND THEIR 15-LIPOXYGENASE INHIBITORY ACTIVITY,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 13, no. 8, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/283196/en

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