SYNTHESIS OF IBUPROFEN WITH MODIFIED AND ECONOMICAL PROCESS AS AN NSAID DRUG

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AHMADI ABBAS; DANIALIA MARZIE; KAZEMIA SARA; AZAMIA SAMIRA; ALIZADEA NOSHIN

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Journal Paper

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Journal: Journal of Applied Chemical Research Year:2014 | Volume:8 | Issue:3 Page(s): 91-95

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Title

SYNTHESIS OF IBUPROFEN WITH MODIFIED AND ECONOMICAL PROCESS AS AN NSAID DRUG

Author(s)

Keywords

NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS)

IBUPROFEN

MODIFIED METHOD WITH IMPROVED AND ECONOMICAL YIELD

Abstract

Ibuprofen (I) is the most widely used non-steroidal anti-inflammatory drugs (NSAIDs) has been synthesized in recent years. NSAIDs are the first choice of drugs that are normally used for the treatment of pain and inflammation. There are many methods for synthesizing of I but each one has some difficulties as raw materials preparation, reaction conditions and etc.In an effort to establish MODIFIED METHOD WITH IMPROVED AND ECONOMICAL YIELD, I was synthesized by the mesylation of ethyl lactate in the presence of triethylamine or pyridine at 273 K to obtain the corresponding ethyl-2-(methylsulphonyloxy) propanoate (II). Then, Friedel-Crafts alkylation of II with isobutylbenzene for single step synthesis of ethyl-2-(4-isobutylphenyl) propanoate (III) was carried out by heating with AlCl3 under neat reaction conditions. Finally, ethyl-2-(4-isobutylphenyl) propanoate (I) formed in 50% yield was hydrolyzed with KOH in methanol and acidified with HCl to afford the desired product.

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APA: Copy

AHMADI, ABBAS, DANIALIA, MARZIE, KAZEMIA, SARA, AZAMIA, SAMIRA, & ALIZADEA, NOSHIN. (2014). SYNTHESIS OF IBUPROFEN WITH MODIFIED AND ECONOMICAL PROCESS AS AN NSAID DRUG. JOURNAL OF APPLIED CHEMICAL RESEARCH (JACR), 8(3), 91-95. SID. https://sid.ir/paper/322925/en

Vancouver: Copy

AHMADI ABBAS, DANIALIA MARZIE, KAZEMIA SARA, AZAMIA SAMIRA, ALIZADEA NOSHIN. SYNTHESIS OF IBUPROFEN WITH MODIFIED AND ECONOMICAL PROCESS AS AN NSAID DRUG. JOURNAL OF APPLIED CHEMICAL RESEARCH (JACR)[Internet]. 2014;8(3):91-95. Available from: https://sid.ir/paper/322925/en

IEEE: Copy

ABBAS AHMADI, MARZIE DANIALIA, SARA KAZEMIA, SAMIRA AZAMIA, and NOSHIN ALIZADEA, “SYNTHESIS OF IBUPROFEN WITH MODIFIED AND ECONOMICAL PROCESS AS AN NSAID DRUG,” JOURNAL OF APPLIED CHEMICAL RESEARCH (JACR), vol. 8, no. 3, pp. 91–95, 2014, [Online]. Available: https://sid.ir/paper/322925/en

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