A SYNTHETIC APPROACH FOR EVALUATION OF CYTOSINEDIAZONIUM SUSCEPTIBILITY

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HAGHBEEN KAMAHLDIN; REZAEIAN SHIMA; BAKAVOLI MEHDI; MIRAZIZI FATEMEH

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Journal: Journal of Applied Chemical Research Year:2017 | Volume:11 | Issue:3 Page(s): 84-96

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Title

A SYNTHETIC APPROACH FOR EVALUATION OF CYTOSINEDIAZONIUM SUSCEPTIBILITY

Author(s)

HAGHBEEN KAMAHLDIN | REZAEIAN SHIMA | BAKAVOLI MEHDI | MIRAZIZI FATEMEH | Issue Writer Certificate

Keywords

4-AMINO-PYRIMIDINE

CYTOSINE

DEAMINATION

DEDIAZOTIZATION

V-TRIAZINE

Abstract

Reaction of a nucleobase with nitrosonium ion leads to its diazotization. Due to the instability, the nucleobase-diazonium assumingly falls in DEDIAZOTIZATION and successive ring opening reactions. The resulting intermediate of the ring opening reaction is able to covalently cross-link the opposite strands of DNA. To examine this assumption for CYTOSINE, some 4-amino-5-cyano pyrimidines were synthesized via [3+3] condensation of amidines with ethoxymethylenemalonitrile and successively converted to the corresponding 4-amino-5-carboxyamido derivatives. These compounds were then exposed to nitrosonium ion under different conditions. Results of this study indicate that the diazonium of a 4-aminopyrimidine prefers DEAMINATION over the DEDIAZOTIZATION. Therefore, the DEDIAZOTIZATION and its successive ring-opening reactions of the pyrimidine cation would happen under some exceptional conditions which deserve to be explored in more detailed studies. In view of the CYTOSINE chemistry and cytotoxicity of NO, the results are presented and discussed.

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APA: Copy

HAGHBEEN, KAMAHLDIN, REZAEIAN, SHIMA, BAKAVOLI, MEHDI, & MIRAZIZI, FATEMEH. (2017). A SYNTHETIC APPROACH FOR EVALUATION OF CYTOSINEDIAZONIUM SUSCEPTIBILITY. JOURNAL OF APPLIED CHEMICAL RESEARCH (JACR), 11(3), 84-96. SID. https://sid.ir/paper/323079/en

Vancouver: Copy

HAGHBEEN KAMAHLDIN, REZAEIAN SHIMA, BAKAVOLI MEHDI, MIRAZIZI FATEMEH. A SYNTHETIC APPROACH FOR EVALUATION OF CYTOSINEDIAZONIUM SUSCEPTIBILITY. JOURNAL OF APPLIED CHEMICAL RESEARCH (JACR)[Internet]. 2017;11(3):84-96. Available from: https://sid.ir/paper/323079/en

IEEE: Copy

KAMAHLDIN HAGHBEEN, SHIMA REZAEIAN, MEHDI BAKAVOLI, and FATEMEH MIRAZIZI, “A SYNTHETIC APPROACH FOR EVALUATION OF CYTOSINEDIAZONIUM SUSCEPTIBILITY,” JOURNAL OF APPLIED CHEMICAL RESEARCH (JACR), vol. 11, no. 3, pp. 84–96, 2017, [Online]. Available: https://sid.ir/paper/323079/en

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