OXIDATIVE STRESS STIMULATES PROTEIN GLYCATION

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MOUSAVI MOVAHEDI ALI AKBAR

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Journal Paper

Paper Information

Journal: MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS Year:2014 | Volume:3 | Issue:SUPPL. (1) Page(s): 57-57

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Information Journal Paper

Title

OXIDATIVE STRESS STIMULATES PROTEIN GLYCATION

Author(s)

MOUSAVI MOVAHEDI ALI AKBAR

Keywords

PROTEIN GLYCATION

OXIDATIVE STRESS

HAS

ROS

PROTEIN FIBRILLATION

POTASSIUM SORBATE

DIABETES TYPE2

Abstract

Urbanization especially in great cities and consequent events like all of chemical and non-chemical pollutions, terrific and intellectual engagement, are the main factors for stress and any concerns in recent word. Oxidative stress arises from transferring of any external stress to the body's internal system which leads to consequent body imbalances and various diseases. In the other word, oxidative stress can be considered as the minor part of all disease procedures and also as a serious imbalance situation between oxidants and anti-oxidants systems. This imbalance increases the formation of unconventional toxic products entitled “free radicals” and especially “ROS”. These compounds are removed from body control system and their interactions with biological macromolecules, especially proteins cause the incontrollable cascade interactions as the new source of toxic free radicals. These results make further damage of biomacromolecules structure, greater toxic compounds, and disrupt the structure and function of tissues and organs eventually. Different types of proteins oxidative modifications can be made directly by interaction with ROS or indirectly via oxidative stress secondary products. Both of these pathways produce the intermediates which are the important toxic products of protein glycation with glucose. So the presence of free radicals and protein oxidation can be the main linkage between protein oxidation and oxidative stress even in the absence glucose. Our research has also demonstrated the protein glycation effect; plenty advanced glycation end products (AGEs) generation and harsh fibrillation of human serum albumin (HSA) upon incubation with industrial preservatives (e.g. potassium sorbate, sodium benzoate, etc) in the absence of glucose.This effect is much more effective relative to incubation of HSA with glucose. Therefore we conclude the industrial preservatives (oxidative stress) can play important and extensive role in diabetes type2 and its complication.

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APA: Copy

MOUSAVI MOVAHEDI, ALI AKBAR. (2014). OXIDATIVE STRESS STIMULATES PROTEIN GLYCATION. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, 3(SUPPL. (1)), 57-57. SID. https://sid.ir/paper/335911/en

Vancouver: Copy

MOUSAVI MOVAHEDI ALI AKBAR. OXIDATIVE STRESS STIMULATES PROTEIN GLYCATION. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS[Internet]. 2014;3(SUPPL. (1)):57-57. Available from: https://sid.ir/paper/335911/en

IEEE: Copy

ALI AKBAR MOUSAVI MOVAHEDI, “OXIDATIVE STRESS STIMULATES PROTEIN GLYCATION,” MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, vol. 3, no. SUPPL. (1), pp. 57–57, 2014, [Online]. Available: https://sid.ir/paper/335911/en

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