DOXORUBICIN-LOADED BILAYER-SURFACE MAGNETITE NANOPARTICLE: A NOVEL VEHICLE FOR ENTRAPMENT OF DRUGS

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SHAHAMAT SEVIL; ROSTAMZADEH MANSOUR SOMAYYEH

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Journal Paper

Paper Information

Journal: MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS Year:2014 | Volume:3 | Issue:SUPPL. (1) Page(s): 286-286

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Information Journal Paper

Title

DOXORUBICIN-LOADED BILAYER-SURFACE MAGNETITE NANOPARTICLE: A NOVEL VEHICLE FOR ENTRAPMENT OF DRUGS

Author(s)

SHAHAMAT SEVIL | ROSTAMZADEH MANSOUR SOMAYYEH

Keywords

DOXORUBICIN

LOADED BILAYER

MAGNETITE NANOPARTICLE

NOVEL VEHICLE

ENTRAPMENT OF DRUGS

Abstract

In the past few decades, Magnetite (Fe3O4) nanoparticles have attracted growing research interest as these materials have many applications in medicine and drug delivery. Coated magnetic particles, called carriers are very useful for delivering chemotherapeutic drugs. We are herein reporting a synthesis of DOXORUBICIN-loaded bilayer-surface MAGNETITE NANOPARTICLEs. The particles were first stabilized with Stearic acid as a primary surfactant, followed by Maleic anhydride-methyl acrylate (MAN-MA) copolymer as a secondary surfactant to form nanoparticles with hydrophobic inner shell and hydrophilic corona. The DOXORUBICIN (DOX) drug was then loaded to modified magnetic nanoparticles. The structural, morphological and magnetic properties of as-prepared sample were characterization by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectra and scanning electron microscopy/energy dispersive X-ray analysis (SEM-EDAX). The magnetic measurements were investigated, using vibrating sample magnetometer (VSM).The particles were exhibited superparamagnetic behavior at room temperature with saturation magnetization (Ms) about 50 emu/g magnetite. We demonstrate that the drug DOX is attached to the nanoparticles surface and the binding of DOX to the nanoparticles was confirmed by FT-IR analysis. The present finding show that DOX loaded nanoparticles coated by copolymer are promising for magnetically targeted drug delivery.

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APA: Copy

SHAHAMAT, SEVIL, & ROSTAMZADEH MANSOUR, SOMAYYEH. (2014). DOXORUBICIN-LOADED BILAYER-SURFACE MAGNETITE NANOPARTICLE: A NOVEL VEHICLE FOR ENTRAPMENT OF DRUGS. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, 3(SUPPL. (1)), 286-286. SID. https://sid.ir/paper/335962/en

Vancouver: Copy

SHAHAMAT SEVIL, ROSTAMZADEH MANSOUR SOMAYYEH. DOXORUBICIN-LOADED BILAYER-SURFACE MAGNETITE NANOPARTICLE: A NOVEL VEHICLE FOR ENTRAPMENT OF DRUGS. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS[Internet]. 2014;3(SUPPL. (1)):286-286. Available from: https://sid.ir/paper/335962/en

IEEE: Copy

SEVIL SHAHAMAT, and SOMAYYEH ROSTAMZADEH MANSOUR, “DOXORUBICIN-LOADED BILAYER-SURFACE MAGNETITE NANOPARTICLE: A NOVEL VEHICLE FOR ENTRAPMENT OF DRUGS,” MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, vol. 3, no. SUPPL. (1), pp. 286–286, 2014, [Online]. Available: https://sid.ir/paper/335962/en

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