INTERACTION OF HUMAN SERUM ALBUMIN AND FENVALERATE; EXPERIMENTAL AND COMPUTATIONAL STUDIES OF ALBUMIN-FENVALERATE INTERACTION

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DAVOODMANESH SAMIRA; HADICHEGENI SHAHRZAD; GOLIAEI BAHRAM; TAGHIZADEH MOHAMMAD; HASHEMI MEHRDAD; TAGHAVI FERESHTEH

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Journal: MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS Year:2014 | Volume:3 | Issue:SUPPL. (1) Page(s): 121-121

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Title

INTERACTION OF HUMAN SERUM ALBUMIN AND FENVALERATE; EXPERIMENTAL AND COMPUTATIONAL STUDIES OF ALBUMIN-FENVALERATE INTERACTION

Author(s)

Keywords

HUMAN SERUM ALBUMIN PROTEIN

FENVALERATE TOXIN

FLUORESCENCE

MOLECULAR MODELING

Abstract

Fenvalerate is an insecticide toxin which has an application in agriculture. We investigated interaction of this toxin with human serum albumin (HSA) which is a carrier for small molecules such as drugs and toxins in the blood stream. In this study, four different methods including UV-VIS, FT-IR, fluorescence spectroscopy and molecular modeling were used to characterize the binding properties of the Fenvalerate to HSA at molecular level under physiological conditions. The experiment performed after incubating the protein and ligand for one day and 30 days. The binding constant which achieved with UV-VIS spectroscopy was 3.78 ´104 M-1, indicating a relatively good binding interaction between ligand and receptor. FT-IR results indicate a decrease in α-helixes and an increase in other structures such as beta-sheets and random coils upon ligand binding, particularly at high concentrations of the ligand. The Fluorescence intensity of HSA decreased regularly with the gradually increasing concentration of Fenvalerate in the mentioned incubation times. These results also were the evidence of ligand binding to the receptor; therefore they confirm the results of the UV-VIS. On the other hand, docking calculations illustrated a potential binding site in the region III-B of HSA. Overall, our results illustrated a binding site for Fenvalerate within HSA which probably suggest a chance for excretion of this toxin from human body with the help of this carrier protein. However, to confirm, the capability of HSA in Fenvalerate excretion from human body further experiments must be perfumed.

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APA: Copy

DAVOODMANESH, SAMIRA, HADICHEGENI, SHAHRZAD, GOLIAEI, BAHRAM, TAGHIZADEH, MOHAMMAD, HASHEMI, MEHRDAD, & TAGHAVI, FERESHTEH. (2014). INTERACTION OF HUMAN SERUM ALBUMIN AND FENVALERATE; EXPERIMENTAL AND COMPUTATIONAL STUDIES OF ALBUMIN-FENVALERATE INTERACTION. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, 3(SUPPL. (1)), 121-121. SID. https://sid.ir/paper/336074/en

Vancouver: Copy

DAVOODMANESH SAMIRA, HADICHEGENI SHAHRZAD, GOLIAEI BAHRAM, TAGHIZADEH MOHAMMAD, HASHEMI MEHRDAD, TAGHAVI FERESHTEH. INTERACTION OF HUMAN SERUM ALBUMIN AND FENVALERATE; EXPERIMENTAL AND COMPUTATIONAL STUDIES OF ALBUMIN-FENVALERATE INTERACTION. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS[Internet]. 2014;3(SUPPL. (1)):121-121. Available from: https://sid.ir/paper/336074/en

IEEE: Copy

SAMIRA DAVOODMANESH, SHAHRZAD HADICHEGENI, BAHRAM GOLIAEI, MOHAMMAD TAGHIZADEH, MEHRDAD HASHEMI, and FERESHTEH TAGHAVI, “INTERACTION OF HUMAN SERUM ALBUMIN AND FENVALERATE; EXPERIMENTAL AND COMPUTATIONAL STUDIES OF ALBUMIN-FENVALERATE INTERACTION,” MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, vol. 3, no. SUPPL. (1), pp. 121–121, 2014, [Online]. Available: https://sid.ir/paper/336074/en

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